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Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Inte…
Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simpl…
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The effects of magnesium-zinc-calcium vitamin D co-supplementation on biomark…
Diabetes is the most common medical condition in pregnant women and its complications affect both mother and fetus. The beneficial effects of vitamin D on gestational diabetes have been shown, though data on the effects of co-administration of vitamin D with other nutrients on pregnancy outcomes in gestational diabetes (GDM) are scarce. This study was aimed to determine the effects of magnesium…
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Calcium supplementation during pregnancy for preventing hypertensive disorder…
Pre-eclampsia and eclampsia are common causes of serious morbidity and death. Calcium supplementation may reduce the risk of preeclampsia, and may help to prevent preterm birth
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Assessment of the nutrient intake and micronutrient status in the first trime…
Maternal nutrition before and during pregnancy is important for a healthy pregnancy outcome. According to National Basic Health Research (Riskesdas) 2013, 24.2% of pregnant women are at risk of chronic malnutrition and 37.1% of them suffer from anemia. The aim of this study was to obtain information about the nutrient intake and serum micronutrient status in the first trimester of pregnant wome…
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What is the role of roflumilast in chronic obstructive pulmonary disease?
Roflumilast has been shown to reduce rates of acute exacerbation in patients with severe chronic obstructive pulmonary disease (COPD), ie, forced expiratory volume in 1 second (FEV1) less than 50% with symptoms of chronic bronchitis and a history of exacerbations. Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor that acts on airway smooth muscle cells and various inflammatory …
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Roflumilast: A Review in COPD
Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor that decreases systemic and pulmonary inflammation and improves disease symptoms in patients with severe chronic obstructive pulmonary disease (COPD). This article reviews the pharmacological properties of roflumilast and its clinical efficacy and tolerability in patients with COPD. Roflumilast is an effective treatment in patients…
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Roflumilast: In Chronic Obstructive Pulmonary Disease
Roflumilast is an orally administered, selective phosphodiesterase 4 inhibitor that is a novel treatment for patients with severe chronic obstructive pulmonary disease (COPD). Across four randomized, double-blind, multinational trials in patients with moderate to severe or severe COPD, roflumilast 500 microg/day produced significantly greater improvements from baseline than placebo in pre- and …
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Eff ect of roflumilast on exacerbations in patients with severe chronic obstr…
Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its eff ect in patients using fi xed combinations of inhaled corticosteroids and longacting β2 agonists is unknown. We postulated that rofl umilast would reduce exacerbations in patients with severe chronic obstructive pulmonary disease at risk for exacerbations, even in combination with inhaled co…
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Roflumilast with long-acting b2-agonists for COPD: influence of exacerbation …
The oral, selective phosphodiesterase type-4 inhibitor roflumilast reduces exacerbations and improves lung function in patients with severe-to-very severe chronic obstructive pulmonary disease (COPD). We investigated the efficacy and safety of roflumilast used concomitantly with long-acting b2- agonists (LABAs) to reduce exacerbations, and the influence of exacerbation history. Pooled data wer…
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The Oxford-Durham Study: A Randomized, Controlled Trial of Dietary Supplement…
Developmental coordination disorder (DCD) affects 5% of school-aged children. In addition to the core deficits in motor function, this condition is associated commonly with difficulties in learning, behavior, and psychosocial adjustment that persist into adulthood. Mounting evidence suggests that a relative lack of certain polyunsaturated fatty acids may contribute to related neurodevelopm…
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