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A Comparison of Morphine, Fentanyl, and Sufentanil Anesthesia for Cardiac Sur…
We compared anesthetic doses of three popular opiates, morphine (n = 10), fentanyl (n = 9), and sufentanil (n = 9) in patients undergoing cardiac surgery. Opiate administration after induction was based upon EEG and cardiovascular signs of the depth of anesthesia. Total doses were morphine, 4.4 ± 0.71 mg/kg, fentanyl, 95.4 ± 9.9 μg/kg, and sufentanil, 18.9 ± 2.2 μg/kg.
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Comparison of Morphine, Meperidine, Fentanyl, and Sufentanil in Balanaced Ane…
This investigation was designed to compare the advantages and disadvantages of the older and less potent narcotics, morphine and meperidine, with fentanyl and sufentanil as components of balanced anesthesia
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Sevoflurane requirements for tracheal intubation with and without fentanyl
We studied 80 healthy ASA I patients (aged 20–52 yr) to determine if fentanyl affects sevoflurane requirements for achieving 50% probability of no movement in response to laryngoscopy and tracheal intubation (MAC-TI). Patients were allocated randomly to one of four fentanyl dose groups (0, 1, 2 and 4 g kg–1). Patients in each group received sevoflurane at a pre-selected end-tidal concentra…
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Fentanyl attenuates cardiovascular responses to tracheal extubation
We carried out a controlled, randomized, double-blind study to examine the cKccts of intravenous fentanyl ( I or 2 pg kg-') on hemodynamic changes during tracheal extubation and emergence from anesthesia in 60 ASA physical status I or I1 patients undergoing elective gynecological surgery. Anesthesia was maintained with 0.5'?'-1.5% isofluranc and 60Yn nitrous oxide (N,Oj in oxygen. Muscle relaxa…
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2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modificat…
Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the…
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Effects of Combination of Ezetimibe and Rosuvastatin on Coronary Artery Plaqu…
In approximately 80% of cardiovascular disease-related deaths, patients suffer from coronary atherosclerotic heart disease.Ezetimibe is the first intestinal cholesterol absorption inhibitor.Its combination with statins for treating coronary atherosclerotic heart disease has attracted attention worldwide
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Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Eze…
The addition of ezetimibe to statin therapy has been reported to result in increased efficacy for reduction of LDL-C levels and achievement of lipid targets, compared with monotherapy
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A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinica…
Combination therapy with ezetimibe and statins is recommended in cases of statin in tolerance or insufficiency. The objective of this study wa to compare the efficacy and safety of combination therapy with ezetimibe and rosuvastatin versus those of rosuvastatin monotherapy in patients with hypercholesterolemia
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The safety of antithrombotic therapy in patients with cerebral microbleeds an…
The impact of cerebral microbleeds on the safety of antithrombotic therapy has recently received considerable attention. We investigated the safety of antithrombotic therapy in patients with cerebral microbleeds and cardiogenic cerebral embolism caused by nonvalvular atrial fibrillation
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Clinical Pharmacology of Eptifibatide
Activation of receptor function of platelet membrane glycoprotein (GP) IIb-IIIa leads to the binding of fibrinogen and is the final common pathway to platelet aggregation. Platelet aggregates provide the structural basis for coronary thrombosis, a major cause of ischemic heart disease. GP IIb-IIIa has a narrow tissue distribution, being found only on platelets and their progenitors, and inh…
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