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Pharmacokinetic Analysis of Levodropropizine and Its Potential Therapeutic Ad…
: Levodropropizine is a non-narcotic, non-centrally acting antitussive that inhibits the cough reflex triggered by neuropeptides. Despite the active clinical application of levodropropizine, the exploration of its inter-individual pharmacokinetic diversity and of factors that can interpret it is lacking. The purpose of this study was to explore effective covariates associated with variation in …
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Effectiveness and Safety of Codeine and Levodropropizine in Patients With Chr…
Recent progress in chronic cough management includes controlling cough triggers and hypersensitivity using antitussives. Therefore, we investigated the effects and safety outcomes of antitussives, codeine and levodropropizine, in patients with chronic cough
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Antitussive Drugs—Past, Present, and Future
Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, and as a problem in its own right in patients with chronic cough of unknown origin. This article reviews our current understanding of the pathogenesis of cough and the hypertussive state characterizing a number of disea…
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Efficacy of levodropropizine in pediatric cough
Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respiratory tract infections. The morbidity associated with acute cough in a child extends also to parents, teachers, and other family members and caregivers. Unfortunately, therapeutic options for acute…
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Cough Suppressant and Pharmacologic Protussive Therapy: ACCP Evidence-Based …
Cough-suppressant therapy, previously termed nonspecific antitussive therapy, incorporates the use of pharmacologic agents with mucolytic effects and/or inhibitory effects on the cough reflex itself. The intent of this type of therapy is to reduce the frequency and/or intensity of coughing on a short-term basis.
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Efficacy and Tolerability of Levodropropizine in Adult Patients with Non-prod…
The results of a double-blind, randomized clinical trial involving 209 adult patients of either sex with moderate non-productive cough are reported. The therapeutic efficacy and the tolerability of levodropropizine syrup (60 mg t.i.d. for 5 days) was evaluated in comparison with dextromethorphan syrup (15 mg t.i.d. for 5 days). Efficacy was assessed by the number of coughing spells in a 6 h per…
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Intrathecal bupivacaine or levobupivacaine: Which should be used for elderly …
To compare two intrathecal anaesthetics, bupivacaine and levobupivacaine, for their effects on motor and sensory blockade and haemodynamics in patients aged 65 years undergoing transurethral resection of the prostate (TUR-P) or transurethral resection of the urinary bladder (TUR-M)
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Levobupivacaine : A Review of its Pharmacology and Use as a Local Anaesthetic
The majority of in vitro, in vivo and human pharmacodynamic studies of nerve block indicate that levobupivacaine has similar potency to bupivacaine. However, levobupivacaine had a lower risk of cardiovascular and CNS toxicity than bupivacaine in animal studies. In human volunteers, levobupivacaine had less of a negative inotropic effect and, at intravenous doses >75mg, produced less prolongatio…
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A Comparison of Spinal Anesthesia with Levobupivacaine and Hyperbaric Bupivac…
Levobupivacaine showed a lower risk of cardiovascular and central nervous system (CNS) toxicity than bupivacaine which is the most popular local anesthetic agent in obstetric practice. The aim of this study was to investigate the clinical efficacy of Levobupivacaine compared with hyperbaric bupivacaine for spinal anesthesia for cesarean section
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Treatment of chronic pain: antidepressant, antiepileptic and antiarrhythmic d…
Chronic pain is complex physiologically and there are many influences on the pain experience. The approach to treatment therefore needs to be multimodal, often with a number of different interventions, both physical and psychological, delivered in parallel
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