Many compounds from plants have been found to play an active role in inhibition and induction of GST activity. This study aims to evaluate the capability of five commonly used medicinal plants in Malaysia to inhibit the glutathione S-transferases (G-ST) activity in vitro
Curcuma longa or turmeric is a tropical plant native to southern and southeastern tropical Asia. A perennial herb belonging to the ginger family, turmeric measures up to 1 m high with a short stem and tufted leaves (Figure 23.1A). The parts used are the rhizomes. Perhaps the most active component in turmeric is curcumin, which may make up 2 to 5% of the total spice in turmeric (Figure 23.1B).
Hepatic encephalopathy is characterized by the development of impaired central nervous system function that may range from trivial abnormalities of consciousness, personality, behaviour and/or intellectual function to deep coma. Hepatic encephalopathy may be clinically invisible, i.e. minimal or sub-clinical, a syndrome that can only be detected by the demonstration of subtle psychometric or …
Both treatment groups were comparable regarding age, gender, etiology of cirrhosis, Child-Pugh class, mental state grade and blood ammonia at baseline. Although, improvement occurred in both groups, there was a greater improvement in L-ornithine-L-aspartate group with regard to both variables. Four patients in the placebo group and 2 in L-ornithine-L-aspartate group died.
Hyperammonemia and associated cerebral edema cause neurological abnormalities in liver disease patients. Although only 15% of ammonia production originates in the colon, management strategies for hepatic encephalopathy (HE) have focused on reducing ammonia generation from the bowel rather than on manipulating systemic mechanisms involved in ammonia metabolism. administration of L-ornithine L-a…
Cough is one of the most common symptoms for which patients seek medical attention from primary care physicians and lung specialists. About 40% of the population at any one time report cough. Cough is associated with significantly impaired health-related quality of life. evodropropizine is an effective and very well tolerated peripheral antitussive drug. We want to compare it to central cough…
Levodropropizine is commonly used as an antitussive drug for acute and chronic cough. It is a non-opioid agent with peripheral antitussive action via the modulation of sensory neuropeptide levels in the airways. Thus, levodropropizine has a more tolerable profile than opioid antitussives. However, we experienced 3 cases of levodropropizine-induced anaphylaxis. Three patients commonly presented …
Cough in children is among the most common symptoms and may have a deep impact on children’s and parents’ sleep and quality of life, thus often requiring an empiric treatment with antitussive agents. Levodropropizine is a very well tolerated peripheral drug, while central cough suppressants (opioids and non opioids) may be associated with side effects that limit their use especially in chil…