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Pharmacokinetics of Moxifloxacin and Levofloxacin in Intensive Care Unit Pati…
Extended daily dialysis (EDD) is increasingly popular in the treatment of acute renal failure (ARF). EDD could remove drugs to a much different degree compared with intermittent standard hemodialysis or continuous renal replacement therapies; however, there are only scarce data on how EDD influences the pharmacokinetics of frequently used drugs. The aim of this study was to determine the pha…
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Moxifloxacin versus levofloxacin against acute exacerbations of chronic bronc…
We compared the efficacy and safety of moxifloxacin and levofloxacin for the treatment of patients with acute exacerbations of chronic bronchitis (AECB) using a prospective, randomized, double blind, parallel-group clinical trial design. A total of 563 patients with AECB were enrolled (437 efficacy-valid) at 34 centers in Mexico, Argentina, Brazil, Colombia, and Peru. Patients were randomized t…
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Moxifloxacin Pharmacokinetics, Cardiac Safety, and Dosing for the Treatment o…
Moxifloxacin is a recommended drug for rifampin-resistant tuberculosis (RR-TB) treatment, but there is limited pediatric pharmacokinetic and safety data, especially in young children. We characterize moxifloxacin population pharmacokinetics and QT interval prolongation and evaluate optimal dosing in children with RR-TB
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Population Pharmacokinetics of Moxifloxacin in Children
Moxifloxacin is a fluoroquinolone that is commonly used in adults, but not children. Certain clinical situations compel pediatric clinicians to use moxifloxacin, despite its potential for toxicity and limited pharmacokinetics (PK) data. Our objective was to further characterize the pharmacokinetics of moxifloxacin in children
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L-Lysine : Monograph
L-Lysine is classified as an essential amino acid; meaning the human body cannot synthesize lysine on its own and thus must rely on adequate dietary intake to function properly. Animal proteins, such as meats, poultry, and milk are rich sources of lysine; proteins from grains, such as wheat and corn, generally tend to be low in lysine. An exception is wheat germ, which contains high amounts of…
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Curcuminoids Lower Plasma Leptin Concentrations: A Meta-analysis
Curcumin is a naturally occurring polyphenol that has been suggested to improve several metabolic diseases. Leptin is an adipokine involved in metabolic status and appetite, with marked crosstalk with other systems. Available data suggest that curcumin may affect leptin levels; therefore, this meta-analysis was performed to evaluate this. A systematic review and meta-analysis were undertaken on…
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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Saf…
Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of cur…
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Curcumin, an active component of turmeric (Curcuma longa), and its effects on…
Turmeric (Curcuma longa) is a type of herb belonging to ginger family, which is widely grown in southern and south western tropical Asia region. Turmeric, which has an importance place in the cuisines of Iran, Malesia, India, China, Polynesia, and Thailand, is often used as spice and has an effect on the nature, color,and taste of foods. Turmeric is also known to have been used for centuries in…
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Curcuma longa: A treasure of medicinal properties
Nature is full of precious treasure to cure us from various disorders. One of them is Curcuma longa belonging to Zingiberaceae family, present with outstanding therapeutic value and used since time immemorial. Part used from the plant is rhizome native to India (south east continent) which is the world's largest producer, consumer and exporter of turmeric. The active principle called curcumin o…
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Curcumin: A Review for Health Benefits
Curcuma longa (Turmeric) is a popular and widely used Indian rhizomatous medicinal plant from the family Zingiberaceae. Curcumin, Demethoxycurcumin (DMC), and Bisdemethoxycurcumin (BDMC) are the constituents of the turmeric and are collectively known as curcuminoids. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) or Diferuloylmethane is well-known for its different biolo…
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