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Efficacy of Isotonic Nasal Wash (Seawater) in the Treatment and Prevention of…
To evaluate the potential of nasal isotonicrnsaline application to prevent reappearance of cold andrnflu in children during the winter
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EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A…
The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 is the update of similar evidence based position papersrnpublished in 2005 and 2007.rnThe document contains chapters on definitions and classification, we now also propose definitions for ??ifficult to treat??nrhinosinusitis, control of disease and better definitions for rhinosinusitis in children. More emphasis is placed on th…
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Nasal irrigation as an adjunctive treatment in allergic rhinitis: A systemati…
Saline nasal irrigation (SNI) is often recommended as additional nonpharmacologic treatment, having proven its efficacy in acute and chronicrnrhinosinusitis and for therapy after sinonasal surgery. To date, however, no systematic review or meta-analysis exists showing the influence of SNI on allergicrnrhinitis (AR). This study aimed to establish the impact of SNI on symptoms of AR in different …
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Oral proliferative verrucous leukoplakia (PVL); open trial of surgery compare…
Proliferative verrucous leukoplakia (PVL) is a unique oral white lesion in which human papillomavirus (HPV) may play a role. PVL behaves far more aggressively than other forms of leukoplakia with a high rate of recurrence after surgical excision, and relentless progression to verrucous hyperplasia and to verrucous or squamous cell carcinomas. The treatment of PVL is usually by surgery, but ther…
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Effect of inosiplex (Isoprinosine®) on induced human influenza A infection
A double blind prospective controlled study to evaluate the effect of inosiplex in induced human influenza A infection was carried out. Inosiplex was administered in therapeutic (starting 48 h following challenge) or prophylactic-therapeutic (starting 48 h prior to challenge) manner in a dose of 4 g per day. Although the number of volunteers with clinical illness in the two treatment groups wa…
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Inosine pranobex is safe and effective for the treatment of subjects with con…
Inosine pranobex (Isoprinosine®) is an immunomodulatory drug approved in several countries for the treatment of viral infections. This study compared the efficacy and safety of inosine pranobex versus placebo in subjects with clinically diagnosed influenza-like illness, including subjects with laboratory-confirmed acute respiratory viral infections. Subgroup analyses evaluated the efficacy o…
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Multicenter randomized study of inosine pranobex versus acyclovir in the trea…
The objective of the study is to evaluate the efficacy and safety of oral inosine pranobex as compared with acyclovir in the treatment of recurrent herpes labialis (RHL) and recurrent herpes genitalis (RHG). A multicenter double-blind, double-dummy, randomized, controlled, parallel group trial was conducted in 144 patients with RHL and 144 RHG.
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THE STUDY ON THERAPEUTIC EFFICACY OF INOSINE PRANOBEX IN CHILDREN
Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The objective of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on the immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. Inosine pranobex (50 mg/kg b.w./day) in divide…
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Allergic Rhinitis and its Impact on Asthma (ARIA):Achievements in 10 years an…
Allergic rhinitis (AR) and asthma represent global healthproblems for all age groups. Asthma and rhinitis frequentlycoexist in the same subjects. Allergic Rhinitis and its Impact onAsthma (ARIA) was initiated during a World HealthOrganizationworkshop in 1999 (published in 2001). ARIA has reclassified AR asmild/moderate-severe and intermittent/persistent
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Leukotrienes and airway inflammation
Asthma is a common chronic inflammatory disease of the airways characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid mediators that contribute to many aspects of asthma pathogenesis. As the LT pathway is relatively steroid-resistant, its blockade by alternative strategies is a desirable component of asthma management. Cysteinyl LT receptor 1 antagonists have …
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