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Efficacy of otilonium bromide in irritable bowel syndrome: a pooled analysis
Otilonium bromide (OB) is a spasmolytic agent acting as an L-type calcium channel antagonist in intestinal and colonic smooth muscle cells (SMCs). We analyzed three independent clinical trials with homogeneous design on patients with irritable bowel syndrome (IBS). After 2 weeks receiving placebo, patients were randomized to receive OB (3 × 40 mg daily) or placebo for 15 weeks. We aimed to per…
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Colonic smooth muscle cells and colonic motility patterns as a target for irr…
Otilonium bromide (OB) is a spasmolytic compound of the family of quaternary ammonium derivatives and has been successfully used in the treatment of patients with irritable bowel syndrome (IBS) due to its specific pharmacodynamic effects on motility patterns in the human colon and the contractility of colonic smooth muscle cells. This article examines how. OB inhibits the main patterns of human…
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Long-term efficacy and safety of otilonium bromide in the management of irrit…
Irritable bowel syndrome (IBS) is a very common functional gastrointestinal disorder characterized by abdominal pain or discomfort and altered bowel habits. The disease affects a large part of the world population. The clinical course is mostly characterized by a cyclic recurrence of symptoms. Therefore, IBS patients should receive, as an initial therapeutic approach, a short course of treatmen…
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Second Asian Consensus on Irritable Bowel Syndrome
There has been major progress in our understanding of the irritable bowel syndrome (IBS), and novel treatment classes have emerged. The Rome IV guidelines were published in 2016 and together with the growing body of Asian data on IBS, we felt it is timely to update the Asian IBS Consensus
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Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes
Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel
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Ticagrelor versus clopidogrel in patients with acute coronary syndromes
Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel.
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Effects of Parecoxib Sodium Application Combined with Enhanced Recovery After…
To study the effect of parecoxib sodium (PS) application, combined with enhanced recovery after surgery (ERAS) nursing, on inflammation and knee joint function in elderly patients after total knee arthroplasty (TKA)
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Parecoxib Sodium does not Impair Platelet Function in Healthy Elderly and Non…
To compare the effects of parecoxib sodium, an injectable prodrug of a cyclo-oxygenase-2—specific inhibitor, and ketorolac on platelet function and bleeding time in elderly individuals and non-elderly adults
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Efficacy of parecoxib on the level of IL-6, CRP, and postoperative pain rel…
The purposes of this study were to investigate the efficacy of parecoxib on postoperative inflammatory response, and to assess serum levels of acute phase reactants, for example cytokine (IL)-6 and C-reactive protein (CRP) in patients who have undergone percutaneous nephrolithotomy (PCNL)
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A clinical trial demonstrates the analgesic activity of intravenous parecoxib…
The purpose of this study was to compare the analgesic activity of 2 doses of parecoxib sodium, ketorolac, and morphine with placebo after gynecologic surgery that requires laparotomy.
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