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Multicenter randomized study of inosine pranobex versus acyclovir in the trea…
The objective of the study is to evaluate the efficacy and safety of oral inosine pranobex as compared with acyclovir in the treatment of recurrent herpes labialis (RHL) and recurrent herpes genitalis (RHG). A multicenter double-blind, double-dummy, randomized, controlled, parallel group trial was conducted in 144 patients with RHL and 144 RHG.
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THE STUDY ON THERAPEUTIC EFFICACY OF INOSINE PRANOBEX IN CHILDREN
Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The objective of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on the immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. Inosine pranobex (50 mg/kg b.w./day) in divide…
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Allergic Rhinitis and its Impact on Asthma (ARIA):Achievements in 10 years an…
Allergic rhinitis (AR) and asthma represent global healthproblems for all age groups. Asthma and rhinitis frequentlycoexist in the same subjects. Allergic Rhinitis and its Impact onAsthma (ARIA) was initiated during a World HealthOrganizationworkshop in 1999 (published in 2001). ARIA has reclassified AR asmild/moderate-severe and intermittent/persistent
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Leukotrienes and airway inflammation
Asthma is a common chronic inflammatory disease of the airways characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid mediators that contribute to many aspects of asthma pathogenesis. As the LT pathway is relatively steroid-resistant, its blockade by alternative strategies is a desirable component of asthma management. Cysteinyl LT receptor 1 antagonists have …
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Add-on montelukast in inadequately controlled asthma patients in a 6-month op…
Bronchial asthma often remains uncontrolled despite treatment with inhaled corticosteroids (ICS), long-acting b2-agonists (LABA) or both, necessitating additional treatment. Patients 18 years (n Z 1681) with mild-to-moderate asthma received oral montelukast 10 mg added to ICS or ICS þ LABAs, and were followed for 6 months in a prospective, open-label observational study. The primary endpoint …
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Role of Montelukast in Asthma and Allergic rhinitis patients
Our objective was to evaluate the effect of Montelukast on the symptoms of asthma and allergic rhinitis (AR), assess its effect on the individual quality of life (QoL), and estimate the proportion of participants having adverse effects
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Clinical, Physiological and AntiInflammatory Effect of Montelukast in Patient…
Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications with antiinflammatory and bronchodilatory properties. Although LTRAs exert antitussive effects in CVA, the mechanisms involved are u…
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Effects of treatment with montelukast alone, budesonide/formoterol alone and …
Whether cysteinyl-leukotriene receptor antagonists (LTRAs) have a similar antitussive effect to inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), and that LTRA plus ICS/LABA is superior to LTRAs alone or ICS/LABA alone in treating cough variant asthma (CVA) remain unclear. This study aimed to investigate and compare the efficacy of montelukast alone, budesonide/formoterol alone an…
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Effectiveness of Ciprofloxacin, Levofloxacin, or Moxifloxacin for Treatment o…
The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic susceptibilities. Rabbit eyes were intrastromally injected with approximately 100 CFU of methicillin sensitive or methicillin-resistant S. aureus (MSSA or MRSA,…
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Penetration of 0.3% ciprofloxacin, 0.3% ofloxacin, and 0.5% moxifloxacin into…
We aimed to quantify the penetration of ciprofloxacin, ofloxacin, and moxifloxacin into the cornea and aqueous humor of cadaver eyes. A total of 60 enucleated eyes, not eligible for corneal transplantation, were divided into three groups and immersed in commercial solutions of 0.3% ciprofloxacin, 0.3% ofloxacin, or 0.5% moxifloxacin for 10 min. Whole corneas and samples of aqueous humor were th…
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