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Darbepoetin Alfa Effectively Maintains Hemoglobin Concentrations at Extended …
Darbepoetin alfa (KRN321) is a novel molecule that stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Due to its three-fold longer half-life and greater biological activity than recombinant human erythropoietin (rHuEPO), KRN321 maintains an effective hemoglobin (Hb) level at extended dose intervals compared with rHuEPO. In this multicenter, open-label study, 513 dial…
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Comparison of recombinant human erythropoietin and darbepoetin alpha in children
The aim was to compare the clinical efficacy of recombinant human erythropoietin (rHuEPO) and darbepoetin alpha (DA) in the treatment of anemia in children with chronic kidney disease (CKD).
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Cigarette Smoke Effects on Innate Immune Mechanisms in the Nasal Mucosa Poten…
It is well established that exposure to cigarette smoke (CS), through active smoking and through exposure to secondhand smoke, has immunosuppressive effects, yet how this might affect the microbiome is not known. In this manuscript we focus on the effects of CS on innate host defense response, with particular emphasis on the role of epithelial cells and mucosal immune responses in the nose and …
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The effect of saline solutions on nasal patency and mucociliary clearance in …
To compare the effect of two saline nasal sprays on nasal patency and mucociliary clearance in patients with rhinosinusitis.
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Efficacy of Isotonic Nasal Wash (Seawater) in the Treatment and Prevention of…
To evaluate the potential of nasal isotonicrnsaline application to prevent reappearance of cold andrnflu in children during the winter
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EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A…
The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 is the update of similar evidence based position papersrnpublished in 2005 and 2007.rnThe document contains chapters on definitions and classification, we now also propose definitions for ??ifficult to treat??nrhinosinusitis, control of disease and better definitions for rhinosinusitis in children. More emphasis is placed on th…
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Nasal irrigation as an adjunctive treatment in allergic rhinitis: A systemati…
Saline nasal irrigation (SNI) is often recommended as additional nonpharmacologic treatment, having proven its efficacy in acute and chronicrnrhinosinusitis and for therapy after sinonasal surgery. To date, however, no systematic review or meta-analysis exists showing the influence of SNI on allergicrnrhinitis (AR). This study aimed to establish the impact of SNI on symptoms of AR in different …
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Oral proliferative verrucous leukoplakia (PVL); open trial of surgery compare…
Proliferative verrucous leukoplakia (PVL) is a unique oral white lesion in which human papillomavirus (HPV) may play a role. PVL behaves far more aggressively than other forms of leukoplakia with a high rate of recurrence after surgical excision, and relentless progression to verrucous hyperplasia and to verrucous or squamous cell carcinomas. The treatment of PVL is usually by surgery, but ther…
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Effect of inosiplex (Isoprinosine®) on induced human influenza A infection
A double blind prospective controlled study to evaluate the effect of inosiplex in induced human influenza A infection was carried out. Inosiplex was administered in therapeutic (starting 48 h following challenge) or prophylactic-therapeutic (starting 48 h prior to challenge) manner in a dose of 4 g per day. Although the number of volunteers with clinical illness in the two treatment groups wa…
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Inosine pranobex is safe and effective for the treatment of subjects with con…
Inosine pranobex (Isoprinosine®) is an immunomodulatory drug approved in several countries for the treatment of viral infections. This study compared the efficacy and safety of inosine pranobex versus placebo in subjects with clinically diagnosed influenza-like illness, including subjects with laboratory-confirmed acute respiratory viral infections. Subgroup analyses evaluated the efficacy o…
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