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A Review of Nebivolol Pharmacology and Clinical Evidence
Nebivolol is a highly selective b1-adrenergic receptor antagonist with a pharmacologic profile that differs from those of other drugs in its class. In addition to cardioselectivity mediated via b1 receptor blockade, nebivolol induces nitric oxide-mediated vasodilation by stimulating endothelial nitric oxide synthase via b3 agonism.
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Use of darbepoetin alfa in the treatment of anaemia of chronic kidney disease…
The introduction of erythropoiesis-stimulating agents (ESAs) into everyday clinical practice has greatly improved the care of patients with chronic kidney disease. ESAs have reduced the need for blood transfusions, improved survival, decreased cardiovascular complications and enhanced patient quality of life. The longer acting ESA, darbepoetin alfa (AranespR ), which can be administered less fr…
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The Efficacy of Darbepoetin Alpha in Hemodialysis Patients Resistant to Human…
Darbepoetin due to longer half life is convenient and effective for long term. This study was done to assess the efficacy of darbepoetin in the treatment of patients on high doses of erythropoietin (EPO) and to compare its efficacy in patients resistant and responsive to EPO. This is a prospective, controlled open label study assessing the efficacy of darbepoetin in 55 hemodialysis patients on …
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Anaemia in haemodialysis patients of five European countries: association wit…
The Dialysis Outcomes and Practice Patterns Study (DOPPS) is a prospective, observational study based on data collected from nationally representative samples of haemodialysis facilities. The burden of anaemia in haemodialysis patients is substantial, leading to considerable morbidity, mortality and reduced quality of life. This study examines anaemia management and outcomes based on data from …
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Erythropoietin to treat head and neck cancer patients with anaemia undergoing…
Anaemia is associated with poor cancer control, particularly in patients undergoing radiotherapy. We investigated whether anaemia correction with epoetin could improve outcome of curative radiotherapy among patients with head and neck cancer.
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Haemoglobin variability and all-cause mortality in haemodialysis patients: A …
Haemoglobin (Hb) variability has been reported to be associated with mortality in dialysis patients in some but not all studies. We aimed to establish the prognostic significance of Hb variability with all-cause mortality in haemodialysis patients through this meta-analysis
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Types of erythropoiesis-stimulating agents and risk of end-stage kidney disea…
Despite the widespread use of erythropoiesisstimulating agents (ESAs) to treat anaemia, the risk of adverse outcomes associated with the use of different types of ESAs in non-dialysis chronic kidney disease (CKD) is poorly investigated
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Breast cancer trial with erythropoietin terminated unexpectedly
Many clinical studies have shown an association between tumour oxygenation, higher haemoglobin concentrations, and improved survival in patients with cancer.1–6 And, in a recent prospective, randomised study, a subpopulation of anaemic patients with metastatic breast cancer were shown to survive longer if given erythropoietin to correct their haemoglobin concentration during chemotherapy than…
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Darbepoetin alpha in lower-than-equimolar doses maintains haemoglobin levels …
The conversion of patients on stable epoetin therapy to darbepoetin alpha is usually carried out according to the ‘1 mg darbepoetin¼200U epoetin’ rule, which is based on the protein content of the two compounds. Since several observations have suggested that this conversion factor leads to an overestimate of the required darbepoetin dose, the present multicentre study was designed to ass…
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Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease
Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency. Recombinant human erythropoietin (epoetin alfa) is indicated for the correction of anemia associated with this condition. However, the optimal level of hemoglobin correction is not defined.
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