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Developments in the packaging of pre-filled syringes
The pre-filled syringe is an increasingly attractive presentation for both new and established parenteral pharmaceuticals and vaccines. In this article, the author explores how innovative carton packaging solutions can enhance this presentation whilst meeting the stringent requirements of both product protection and environmental sustainability. He analyses recent developments in the packaging …
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Ketorolac: a review of its pharmacodynamic and pharmacokinetic properties and…
Ketorolac is a non-steroidal agent with potent analgesic and moderate antiinflammatory activity. It is administered as the tromethamine salt orally, intramuscularly, intravenously, and as a topical ophthalmic solution. Clinical studies indicate single-dose efficacy greater than that of morphine, pethidine (meperidine) and pentazocine in moderate to severe postoperative pain, with some evidence …
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Ketorolac tromethamine as compared with morphine sulfate for treatment of pos…
Ketorolac tromethamine, a nonnarcotic, prostaglandin synthesisinhibiting analgesic, was compared with morphine sulfate for relief of moderate to severe postoperative pain. The 155 patient participants received single intramuscular doses of either ketorolac, 10, 30, or 90 mg, or morphine, 6 or 12 mg, administered in a double-blind, randomized fashion. Pain scores (verbal and visual analog) were …
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Prefilled syringe: a review of injectable dosage form delivery system
Prefilled syringe are convenient device for the drug delivery of parental dosage form. There is easy to makes and delivering the precise dosage of the medication. The content of this review article is component of Prefilled syringe, application of Prefilled syringe, compatibility study of the drug product with the packing material, Extractable and leachable and challenge’s with the Prefilled …
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Comparison of intravenous ketorolac at three doses for treating renal colic i…
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that is extensively used for the management of renal colic in the emergency department (ED). It has been proposed that ketorolac is used at doses above its analgesic ceiling with no more advantages and increased risk of adverse effects. In this study, we compared the analgesic effects of three doses of intravenous ketorol…
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Novel Regenerative Nanofibrous Bio-device for Dural Defect Repair
Dural defect is a common problem following posterior fossa surgery and needs to be repaired timely so as to prevent the leakage of cerebrospinal fluid (CSF). Currently, there are a few alternatives to human dura mater; however, each has its respective shortcomings such as limited availability, risk of animal pathogens, and poor biocompatibility. To address these issues, we have recently develo…
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Simultaneous determination of 11 related impurities in propofol by gas chroma…
A variety of related impurities, including starting materials, process impurities, and degradation products, can be detected in propofol. In this article, a sensitive and selective GC-MS/MS method using pulsed splitless injection technique for the determination of 11 main related impurities in propofol in one chromatogram is investigated. This method is extensively validated for its linearity, …
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Recovery profile and side effects of remifentanil-based anaesthesia with desf…
Nitrous oxide (N2O) has been suggested to contribute to bowel distension, resulting in worsened operating conditions for laparoscopic surgery, and to increase incidence of postoperative nausea and vomiting. Therefore, our objective was to assess the feasibility of two remifentanil-based anaesthetic regimens free from N2O with special regard to recovery profile, postoperative analgesic demand an…
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Changes in Concentrations of Free Propofol by Modification of the Solution
Because free propofol is thought to be responsible for pain on injection, we investigated the changes in concentrations of free propofol by modifying two kinds of propofol products in a medium- and long-chain triglyceride (MCT/LCT) emulsion and in an LCT emulsion. The techniques used in this study were 1) mixing 2% lidocaine (10:1), 2) mixing 5% dextrose in acetated Ringer’s solution to r…
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Avoiding propofol injection pain in children: a prospective, randomized, doub…
Pain on injection limits the use of propofol in children. The combination of lidocaine and propofol is widely used to reduce pain. A new solvent [medium-chain triglyceride (mct)/long-chain triglyceride (lct)] has been advocated to be less painful than standard (lct) propofol in adults, but no information is available of its usefulness in pre-school children. We designed a prospective, randomiz…
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