Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of S…

A multicentre, open-label, randomized study was performed in 501 out-patients with acute otitis media, aged 6–36 months, to study the impact of treatment with either cefixime suspension 8 mg/kg/day bd or co-amoxiclav suspension 80 mg/kg/day tds for 10 days on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae. Of 426 patients with nasopharyngeal cultures at entry …

Cefixime: a review of its antibacterial activity, pharmacokinetic properties …

Cefixime, previously designated FK027, FR17027 and CL284635, is an orally active cephalosporin with a broad spectrum of antibacterial activity in vitro. It is particularly active against many Enterobacteriaceae, Haemophilus influenzae. Streptococcus pyogenes, Streptococcus pneumoniae and Branhamella catarrhalis, and is resistant to hydrolysis by many beta-lactamases. Cefixime has little activit…

EFFICACY OF CEFIXIME IN THE TREATMENT OF URINARY TRACT INFECTION

A urinary tract infection (UTI) (also known as acute cystitis or bladder infection) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a simple cystitis (a bladder infection) and when it affects the upper urinary tract it is known as pyelonephritis (a kidney infection).

The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 rece…

Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide has been shown to interfere with the mobilization of calcium in intestinal smooth muscle, but the effects on other intestinal tissues have not been investigated. We identifed the muscarinic receptor subtype coupled to calcium signals in colonic crypt derived from the human c…

A DISTRIBUTION STUDY WITH 14C-OTILONIUM BROMIDE IN THE RAT: EVIDENCE FOR SELE…

The aim of this study was to determine the plasma levels and the tissue distribution of otilonium bromide, measured as total radioactivity, after oral administration of 2 mg/kg of 14C-labeled drug to rats. Radioactivity levels were very low in the plasma (ranging from 2.7 ng Eq/ml at 1.5 h to 0.6 ng Eq/ml at 24 h) as compared with those found in the gastrointestinal (GI) tract, indicating negli…

Otilonium bromide enhances sensory thresholds of volume and pressure in patie…

Visceral hyperalgesia has been suggested to play a role in the development of symptoms presented by irritable bowel syndrome patients. Otilonium bromide was developed to block smooth muscle Ca release to control crampingpain of these patients. Aims: to determine whether otilonium bromide can influence sensory thresholds of patients sufferingfrom irritable bowel syndrome.

COMPARATIVE EFFICACY OF LOW- AND HIGHMOLECULAR WEIGHT INTRA-ARTICULAR HYALURO…

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

-

Viscosupplementation for the treatment of osteoarthritis of the knee

To assess the effects of viscosupplementation in the treatment of OA of the knee. The products were hyaluronan and hylan derivativesrn(Adant, Arthrum H, Artz (Artzal, Supartz), BioHy (Arthrease, Euflexxa, Nuflexxa), Durolane, Fermathron, Go-On, Hyalgan, HylanrnG-F 20 (Synvisc Hylan G-F 20), Hyruan, NRD-101 (Suvenyl), Orthovisc, Ostenil, Replasyn, SLM-10, Suplasyn, Synject and Zeelrncompositum).

The role of intra-articular hyaluronan (Sinovial) in the treatment of osteoar…

Osteoarthritis (OA) leads to significant pain and disability. For pain relief, a tailored approach using non-pharmacological and pharmacological therapies is recommended. If adequate symptom relief is not achieved with acetaminophen, other pharmacological options include non-steroidal anti-inflammatory drugs (NSAIDs), topical analgesics, intra-articular corticosteroids and intraarticular hyalur…

Which is most pungent: isoflurane, sevoflurane or desflurane?

We compared the pungency and tolerability of three inhaled anaesthetics in a randomized, double-blind study. Eighty-one unpremedicated patients (n=27, each group) inhaled 2 MAC of isoflurane (2.3%), desflurane (12%) or sevoflurane (4%) for 60 s from an anaesthetic breathing circuit via a mask. Two blinded observers recorded coughing, complaints of burning and irritation, and how long the in…