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Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate
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Efficacy and safety of fluticasone propionate/formoterol fumarate in pediatri…
The efficacy and safety of fluticasone propionate/formoterol fumarate pressurized metered-dose inhaler (pMDI) (fluticasone/formoterol; Flutiform®; 100/10 µg b.i.d.) was compared with fluticasone propionate (Flixotide® Evohaler® pMDI; 100 µg b.i.d.) and fluticasone/salmeterol (Seretide® Evohaler® pMDI; 100/50 µg b.i.d.) in a pediatric asthma population (EudraCT number: 2010-024635-16)
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Combination fluticasone and salmeterol versus fixed dose combination budesoni…
Combination therapies are frequently recommended as maintenance therapy for people with asthma, whose disease is not adequately controlled with inhaled steroids. Fluticasone/salmeterol (FP/SAL) and budesonide/formoterol (BUD/F) have been assessed against their respective monocomponents, but there is a need to compare these two therapies on a head-to-head basis.
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PREFILLED SYRINGES: INNOVATIONS THAT MEET THE GROWING DEMAND
The use of prefilled syringes is a modern way to apply parenteral drugs. With the achievements in science and technology in the past twenty years an increasing number of injectables apply prefilled syringes. The benefits compared with vial-disposable syringe concepts are obviously convenience and ease of handling as well as advantages in safety and a reduction of drug overfill
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Developments in the packaging of pre-filled syringes
The pre-filled syringe is an increasingly attractive presentation for both new and established parenteral pharmaceuticals and vaccines. In this article, the author explores how innovative carton packaging solutions can enhance this presentation whilst meeting the stringent requirements of both product protection and environmental sustainability. He analyses recent developments in the packaging …
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Ketorolac: a review of its pharmacodynamic and pharmacokinetic properties and…
Ketorolac is a non-steroidal agent with potent analgesic and moderate antiinflammatory activity. It is administered as the tromethamine salt orally, intramuscularly, intravenously, and as a topical ophthalmic solution. Clinical studies indicate single-dose efficacy greater than that of morphine, pethidine (meperidine) and pentazocine in moderate to severe postoperative pain, with some evidence …
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Ketorolac tromethamine as compared with morphine sulfate for treatment of pos…
Ketorolac tromethamine, a nonnarcotic, prostaglandin synthesisinhibiting analgesic, was compared with morphine sulfate for relief of moderate to severe postoperative pain. The 155 patient participants received single intramuscular doses of either ketorolac, 10, 30, or 90 mg, or morphine, 6 or 12 mg, administered in a double-blind, randomized fashion. Pain scores (verbal and visual analog) were …
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Prefilled syringe: a review of injectable dosage form delivery system
Prefilled syringe are convenient device for the drug delivery of parental dosage form. There is easy to makes and delivering the precise dosage of the medication. The content of this review article is component of Prefilled syringe, application of Prefilled syringe, compatibility study of the drug product with the packing material, Extractable and leachable and challenge’s with the Prefilled …
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Comparison of intravenous ketorolac at three doses for treating renal colic i…
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that is extensively used for the management of renal colic in the emergency department (ED). It has been proposed that ketorolac is used at doses above its analgesic ceiling with no more advantages and increased risk of adverse effects. In this study, we compared the analgesic effects of three doses of intravenous ketorol…
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Novel Regenerative Nanofibrous Bio-device for Dural Defect Repair
Dural defect is a common problem following posterior fossa surgery and needs to be repaired timely so as to prevent the leakage of cerebrospinal fluid (CSF). Currently, there are a few alternatives to human dura mater; however, each has its respective shortcomings such as limited availability, risk of animal pathogens, and poor biocompatibility. To address these issues, we have recently develo…
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