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Clinical Safety and Efficacy of Clopidogrel-Implications of the Clopidogrel v…
Clopidogrel is a new antiplatelet agent that has recently been approved in the United States for the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease (PAD).
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A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in pat…
Combined pegylated interferon and ribavirin has improved chronic hepatitis C (CH-C) therapy; however, sustained virological response is achieved in only about half of the patients with a 1b genotype infection. We assessed oral ursodeoxycholic acid (UDCA) on serum biomarkers as a possible treatment for interferon non-responders
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New Therapeutical Indications of Ursodeoxycholic Acid
Until the 1980s the role of bile acids in the initiation of liver injury in man was only suspected on the basis of the toxicity of whole bile and bile salts, and of studies showing elevations in serum and tissue levels of bile salts in liver diseases. The beneficial effects of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis have provided the first firm evidence that bile acids may in s…
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Gallstone disease
Gallstone disease is one of the most prevalent gastrointestinal diseases with a substantial burden to health care systems that is supposed to increase in ageing populations at risk
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Use of ursodeoxycholic acid in liver diseases
Ursodeoxycholic acid is currently the only established drug for the treatment of chronic cholestatic liver diseases. It has cytoprotective, anti-apoptotic, membrane stabilizing, anti-oxidative and immunomodulatory effects. Prolonged administration of ursodeoxycholic acid in patients with primary biliary cirrhosis (PBC) is associated with survival benefit and a delaying of liver transplantation
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EASL Clinical Practice Guidelines: Management of cholestatic liver diseases
EASL Clinical Practice Guidelines (CPG) on the management of cholestatic liver diseases define the use of diagnostic, therapeutic and preventive modalities, including non-invasive and invasive procedures, in the management of patients with cholestatic liver diseases
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The efficiency of sucralfate in corrosive esophagitis: A randomized, prospect…
Ingestion of a chemical agent is a serious problem, and several treatment protocols to prevent stricture formation have been proposed. We conducted a randomized prospective study to evaluate the effectiveness of oral intensive sucralfate plus conventional therapy compared to conventional therapy alone
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Effect of sucralfate vs antacids on gastric pathogens: results of a double-bl…
Unblinded studies suggested that sucralfate prophylaxis for stress is associated with a lower rate of nosocomial pneumonia than acid-reducing approaches. We performed a randomized, double blind, double-sham clinical trial comparing the exact microbial effects of each treatment
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A COMPARISON OF SUCRALFATE AND RANITIDINE FOR THE PREVENTION OF UPPER GASTROI…
Critically ill patients who require mechanical ventilation are at increased risk for gastrointestinal bleeding from stress ulcers. There are conflicting data on the effect of histamine H2-receptor antagonists and the cytoprotective agent sucralfate on rates of gastrointestinal bleeding, ventilator-associated pneumonia, and mortality
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Diagnostic approach & pharmacological treatment regimen of Peptic Ulcer Disease
Peptic ulcer is an acid related disorder of gastrointestinal tract. Gastritis, erosions, and peptic ulcer of the upper astrointestinal (GI) tract require gastric acid for their formation. Peptic Ulcer Disease differs from gastritis and erosions in those ulcers typically extend deeper into the muscularis mucosa. There are three common forms of peptic ulcers, Helicobacter pylori associated, non-…
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