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Quantifying effect of statins on low density lipoprotein cholesterol, ischaem…
To determine by how much statins reduce serum concentrations of low density lipoprotein (LDL) cholesterol and incidence of ischaemic heart disease (IHD) events and stroke, according to drug, dose, and duration of treatment.
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The effect of atorvastatin on serum lipids and lipoproteins in patients with …
The efficacy of atorvastatin, a new hydroxymethylglutaryl (HMG)-CoA reductase inhibitor, in reducing serum lipid levels, modifying lipoprotein composition, and suppressing cholesterol synthesis was evaluated in patients with homozygous familial hypercholesterolemia (homozygous FH) undergoing LDL-apheresis therapy. Atorvastatin was given in escalating doses (10, 20, and 40 mg:day) to nine patien…
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CEFIXIME: A PHARMACOECONOMIC PERSPECTIVE
Cefixime, the first oral third-generation cephalosporin available, is commonly used for the treatment of upper and lower respiratory tract infections, otitis media, sinusitis, urinary tract infections, and gonorrhea. The drug has a number of characteristics that make it effective when administered once or twice daily: a half-life of 3 to 4 hours, activity against most common pathogens involved …
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Double-Blind Study Comparing 3-Day Regimens of Cefixime and Ofloxacin in Trea…
This double-blind randomized study compared 3-day regimens of cefixime (400 mg once daily) and ofloxacin (200 mg twice a day) in the treatment of urinary tract infections in women. The respective clinical cure rates for the two groups of women were 89 and 92% after 7 days and 81 and 84% after 4 weeks. The respective microbiological cure rates (free of bacteriuria) for the two groups of women we…
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Effects of cefixime or co-amoxiclav treatment on nasopharyngeal carriage of S…
A multicentre, open-label, randomized study was performed in 501 out-patients with acute otitis media, aged 6–36 months, to study the impact of treatment with either cefixime suspension 8 mg/kg/day bd or co-amoxiclav suspension 80 mg/kg/day tds for 10 days on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae. Of 426 patients with nasopharyngeal cultures at entry …
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Cefixime: a review of its antibacterial activity, pharmacokinetic properties …
Cefixime, previously designated FK027, FR17027 and CL284635, is an orally active cephalosporin with a broad spectrum of antibacterial activity in vitro. It is particularly active against many Enterobacteriaceae, Haemophilus influenzae. Streptococcus pyogenes, Streptococcus pneumoniae and Branhamella catarrhalis, and is resistant to hydrolysis by many beta-lactamases. Cefixime has little activit…
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EFFICACY OF CEFIXIME IN THE TREATMENT OF URINARY TRACT INFECTION
A urinary tract infection (UTI) (also known as acute cystitis or bladder infection) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a simple cystitis (a bladder infection) and when it affects the upper urinary tract it is known as pyelonephritis (a kidney infection).
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The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3 rece…
Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide has been shown to interfere with the mobilization of calcium in intestinal smooth muscle, but the effects on other intestinal tissues have not been investigated. We identifed the muscarinic receptor subtype coupled to calcium signals in colonic crypt derived from the human c…
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A DISTRIBUTION STUDY WITH 14C-OTILONIUM BROMIDE IN THE RAT: EVIDENCE FOR SELE…
The aim of this study was to determine the plasma levels and the tissue distribution of otilonium bromide, measured as total radioactivity, after oral administration of 2 mg/kg of 14C-labeled drug to rats. Radioactivity levels were very low in the plasma (ranging from 2.7 ng Eq/ml at 1.5 h to 0.6 ng Eq/ml at 24 h) as compared with those found in the gastrointestinal (GI) tract, indicating negli…
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Otilonium bromide enhances sensory thresholds of volume and pressure in patie…
Visceral hyperalgesia has been suggested to play a role in the development of symptoms presented by irritable bowel syndrome patients. Otilonium bromide was developed to block smooth muscle Ca release to control crampingpain of these patients. Aims: to determine whether otilonium bromide can influence sensory thresholds of patients sufferingfrom irritable bowel syndrome.
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