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Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals
Mammalian fetal skin regenerates perfectly, but adult skin repairs by the formation of scar tissue. The cause of this imperfect repair by adult skin is not understood. In contrast, wounded adult amphibian (urodeles and anurans) skin is like mammalian fetal skin in that it repairs by regeneration, not scarring. Scar-free wound repair in adult Xenopus is associated with expression of the paired …
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Metabolic syndrome update
The metabolicsyndromeisamultiplexriskfactorforatheroscleroticcardiovasculardiseaseandtype2diabetes.Itiscomposed of atherogenicdyslipidemia,elevatedbloodpressure,insulinresistanceandelevatedglucose,apro-thromboticstate,anda pro-inflammatorystate.Excessenergyintakeandconcomitantobesityarethemajordriversofthesyndrome.Lifestyle intervention canreversemetabolicriskfactors,butattimes,drugtherapies…
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Metabolic syndrome : Pathophysiology, Management, and Modulation by Natural C…
Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and atherogenic dyslipidemia, and is strongly associated with an increased risk for developing diabetes and atherosclerotic and nonatherosclerotic cardiovascular disease (CVD). The pathogenesis of MetS involves both genetic and acquired factors that contribut…
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Use of Oral Anti-Diabetic Agents in Pregnancy: A Pragmatic Approach
Insulin is the gold standard for treatment of hyperglycemia during pregnancy, when lifestyle measures do not maintain glycemic control during pregnancy. However, recent studies have suggested that certain oral hypoglycemic agents (metformin and glyburide) may be safe and be acceptable alternatives. There are no serious safety concerns with metformin, despite it crossing the placenta.
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Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practic…
The objective is to formulate clinical practice guidelines for the treatment of diabetes in older adults.
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KONSENSUS PENGELOLAAN DAN PENCEGAHAN DIABETES MELITUS TIPE 2 DI INDONESIA : 2015
Hiperglikemia adalah suatu kondisi medik berupa peningkatan kadar glukosa dalam darah melebihi batas normal. Hiperglikemia merupakan salah satu tanda khas penyakit diabetes mellitus (DM), meskipun juga mungkin didapatkan pada beberapa keadaan yang lain. Saat ini penelitian epidemiologi menunjukkan adanya kecenderungan peningkatan angka insidensi dan prevalensi DM tipe-2 di berbagai penjuru du…
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Clinical effectiveness and safety of vildagliptin in >19,000 patients with ty…
The present GUARD study was a prospective, non-interventional study evaluating the clinical effectiveness, safety and tolerability of vildagliptin with or without metformin in adult patients with type 2 diabetes mellitus (T2DM) studied in routine clinical practice. Patients were enrolled from countries across four geographical regions. The primary endpoint was change in glycated haemoglobin (Hb…
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Comparison of vildagliptin and sitagliptin in patients with type 2 diabetes a…
At their recommended doses for severe RI, vildagliptin (50 mg once daily) compared with sitagliptin (25 mg once daily) demonstrated similar efficacy and both drugs were well tolerated. This study provides further support for the use of DPP-4 inhibitors in patients with severe RI
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Efficacy and safety of vildagliptin, sitagliptin, and linagliptin as add-on t…
We aimed to evaluate the efficacy and safety of the three dipeptidyl peptidase 4 (DPP-4) inhibitors (vildagliptin, sitagliptin, and linagliptin) as add-on therapy in Chinese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on dual combination of insulin and metformin or acarbose
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Continuous glucose profiles with vildagliptin versus sitagliptin in add-on to…
To compare continuous glucose monitoring (CGM) profiles on vildagliptin versus sitagliptin in addition to metformin, in patients with inadequately controlled type 2 diabetes mellitus (HbA(1c) 6.5-8.0%).
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