Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colo…

Despite extensive randomized evidence supporting the use of treatment breaks in metastatic colorectal cancer (mCRC), they are not universally offered to patients despite improvements in quality of life without detriment to overall survival (OS). FOCUS4-N was set up to explore the impact of oral maintenance therapy in patients who are responding to first-line therapy

Capecitabine for hormone receptor-positive versus hormone receptor-negative b…

Retrospective analyses suggest that capecitabine may carry superior activity in hormone receptor-positive relative to hormone receptornegative metastatic breast cancer. This review examined the veracity of that finding and explored whether this diJerential activity extends to early breast cancer

Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy

Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)–negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear.

Oral Capecitabine Compared With Intravenous Fluorouracil Plus Leucovorin in P…

To compare the efficacy and safety of orally administered capecitabine (Xeloda; Roche Laboratories, Inc, Nutley, NJ), a novel fluoropyrimidine carbamate designed to mimic continuous fluorouracil (5-FU) infusion but with preferential activation at the tumor site, with that of intravenous (IV) 5-FU plus leucovorin (5-FU/LV) as first-line treatment for metastatic colorectal cancer

Superior Survival With Capecitabine Plus Docetaxel Combination Therapy in Ant…

Docetaxel and capecitabine, a tumor-activated oral fluoropyrimidine, show high single-agent efficacy in metastatic breast cancer (MBC) and synergy in preclinical studies. This international phase III trial compared efficacy and tolerability of capecitabine/docetaxel therapy with single-agent docetaxel in anthracycline- pretreated patients with MBC.

Clinical Management of Localized Colon Cancer with Capecitabine

Large randomized trials demonstrated a benefit of adjuvant chemotherapy after resection of the primary colon cancer. It improves overall survival and reduces the risk of death, by 5% in UICC (Union Internationale Contre le Cancer) stage II and approximately 15%–20% in stage III. Fluoropyrimidines have been the standard drugs for the treatment of colon cancer since large randomized controlled …

Photoageing: mechanism, prevention and therapy

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Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up

Purpose Regular sunscreen use prevents cutaneous squamous cell carcinoma long term, but the effect on melanoma is highly controversial. We evaluated whether long-term application of sunscreen decreases risk of cutaneous melanoma

Evaluation and management of variceal bleeding

Acute variceal bleeding is one of the most fatal complications of cirrhosis and is responsible for about one-third of cirrhosis-related deaths.Therefore,every effort should be made to emergently resuscitate the patients,start pharma-cotherapy as soon as possible and do endoscopic therapy in a timely manner. Despite there cent advances in treatment, mortality rate is still high.We provide a comp…

Radiation Colitis and Proctitis

Radiation therapy is commonly utilized as a major component in the treatment of pelvic malignancy. Unfortunately, secondary toxicity to the lower gastrointestinal tract can occur. This most commonly affects the rectum, although injuries to the colon and small intestine are not uncommon. The presentation can be acute or chronic, and different mechanisms are responsible for each. Symptomatology i…