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Vitamin D supplementation to prevent acute respiratory infections: systematic…
A 2017 meta-analysis of data from 25 randomised controlled trials of vitamin D supplementation for the prevention of acute respiratory infections revealed a protective effect of the intervention. Since then, 20 new RCTs have been completed
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Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy
Preclinical and early clinical research indicates that Vitamin D3 may reduce seizures in both animal models and open-label clinical trials
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Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Di…
Cardiovascular disease (CVD) risk factors are associated with low serum 25 hydroxyvitamin D (25(OH)D) concentrations in observational studies; however, clinical trial findings are inconsistent
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Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with …
Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS.
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Influence of Vitamin D supplementation on reproductive outcomes of infertile …
Low vitamin D status has been associated with an increased risk for infertility. Recent evidence regarding the efficacy of vitamin D supplementation in improving reproductive outcomes is inconsistent. Therefore, this systematic review was conducted to investigate whether vitamin D supplementation could improve the reproductive outcomes of infertile patients and evaluate how the parameters of…
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Vitamin D Supplementation During Pregnancy: Double-Blind, Randomized Clinical…
The need, safety, and effectiveness of vitamin D supplementation during pregnancy remain controversial. In this randomized, controlled trial, women with a singleton pregnancy at 12 to 16 weeks’ gestation received 400, 2000, or 4000 IU of vitamin D3 per day until delivery. The primary outcome was maternal/neonatal circulating 25-hydroxyvitamin D [25(OH)D] concentration at delivery, with seco…
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Preparation of delayed-release multiparticulate formulations of diclofenac so…
Diclofenac sodium was used as a model drug for preparation of delayed-release (DR) multiparticulates, which were further processed into solid oral dosage forms such as capsules and tablets. Multiple unit pellets systems (MUPS) were prepared from different types of starter pellets (inert cores) including microcrystalline cellulose pellets, sugar spheres, isomalt pellets and novel calcium phospha…
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Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, …
Oral modified-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form is preferred over hard gelatin capsules. Moreover, multiparticulate tablets are a promising solu…
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Anticholinergics in the treatment of children and adults with acute asthma: a…
Current guidelines recommend the use of a combination of inhaled b2 agonists and anticholinergics, particularly for patients with acute severe or life threatening asthma in the emergency setting. However, this statement is based on a relatively small number of randomised controlled trials and related systematic reviews. A review was undertaken to incorporate the more recent evidence available a…
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Combined inhaled beta-agonist and anticholinergic agents for emergency manage…
Inhaled short-acting anticholinergics (SAAC) and short-acting beta -agonists (SABA) are effective therapies for adult patients with acute asthma who present to the emergency department (ED). It is unclear, however, whether the combination of SAAC and SABA treatment is more effective in reducing hospitalisations compared to treatment with SABA alone
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