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Immune checkpoint therapy for non-smallcell lung cancer: an update
The role of immunotherapy in treatment of non-small-cell lung cancer (NSCLC) has been gaining interest over the past few years. This has been driven primarily by promising results from trials evaluating antagonist antibodies that target coinhibitory immune checkpoints expressed on tumor cells and immune cells within the tumor microenvironment. Immune checkpoints exist to dampen or terminate…
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Polysaccharide biological response modifiers
Biological response modifiers (BRMs) are substances which augment immune response. BRMs can be cytokines which are produced endogenously in our body by immune cells or derivatives of bacteria, fungi, brown algae, Aloe vera and photosynthetic plants. Such exogeneous derivatives (exogeneous BRMs) can be nucleic acid (CpG), lipid (lipotechoic acid), protein or polysaccharide in nature. The recepto…
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Experience with Administration of Modified Arabinoxylan from Rice Bran (BioBr…
The functional food, rice bran arabinoxylan derivative (BioBran/MGN-3), was administered over a long period t patients with rheumatoid arthritis given mainly symptomatic treatment with steroids, to evaluate its supplementary effect with respresentative treatments fr rheumatism, such as steroids, analgesics, and thermtehrapy
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Experience with administration of modified Arabinoxylan from rice bran (BioBr…
The functional food, rice bran arabinoxylan derivative (BioBran/MGBN-3), was administered over a long period to patients with rheumatoid arthritis given mainly symptomatic treatment with steroids, to evaluate its supplementary effect with respresentative treatment for rheumatism, such as steroids, analgesics and thermotherapy
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Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapi…
This study examined the efficacy of arabinoxylan rice bran (MGN-3) in conjunction with an interventional therapy (IT) for the treatment of hepatocellular carcinoma patients. Patients and Methods: A total of sixty-eight patients with hepatocellular carcinoma (stages I and II) participated in the study. Patients were randomized to receive IT (30 patients, control group) or IT+MGN-3 (38 patients)…
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Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-i…
We have recently demonstrated that breast cancer cell (BCC) lines undergo apoptosis following phagocytosis of S. cerevisiae. Arabinoxylan rice bran extract (MGN-3/Biobran) has been shown to enhance this effect. Since previous data were obtained using cells in suspension, the present study was undertaken to examine monolayer BCC that more closely model cancer cell growth. Monolayers of both brea…
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Gastric Cancer:Risk Factors, Diagnosis and Management
Gastric cancer (GC) is the most common cancer with high mortality worldwide.Highrate of GC deaths reported in China, Japan, and Korea. There are 56% new cases from Eastern Asia,41% from China,and11% from Japan. The common causes of GC include Helicobacter pylori infection which accounts for 60% of cases, pickled vegetables, smoking, alcohol intake and genetics. GC is often asymptomatic or nonsp…
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Gastric cancer: epidemiology, prevention, classification, and treatment
Gastric cancer is the second most common cause of cancer-related deaths in the world, the epidemiology of which has changed within last decades. A trend of steady decline in gastric cancer incidence rates is the effect of the increased standards of hygiene, conscious nutrition, and Helicobacter pylori eradication, which together constitute primary prevention. Avoidance of gastric cancer remain…
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Effect of Reduced-Dose Capecitabine Plus Cetuximab as Maintenance Therapy for…
Fluorouracil-based chemotherapy combined with anti–epidermal growth factor receptor/vascular endothelial growth factor therapy is the standard first-line treatment for metastatic colorectal cancer followed by low-intensity maintenance therapy to balance the clinical efficacy and adverse effects (AEs). However, there have been concerns about the AEs of capecitabine plus cetuximab as a mainten…
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Capecitabine in the routine first-line treatment of elderly patients with adv…
The purpose of this observational study was to evaluate feasibility, efficacy results and toxicity observations of capecitabine in routine first line treatment of patients with metastatic colorectal cancer, with particular regard of elderly patients (>75 years of age
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