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Study on the preventive effect of intravenous esomeprazole in the management …
This retrospective study investigated the preventive effect of intravenous esomeprazole (IVEO) in the prevention of nonvarices upper gastrointestinal bleeding (NUGIB). This study enrolled 130 patients with NUGIB and all of them underwent successful endoscopic hemostasis, of which 65 cases received routine management and IVEO (Group A) and the other 65 cases received routine management alone (G…
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Pharmacological Treatment of Diabetic Neuropathic Pain
Neuropathic pain continues to be a difficult and challenging clinical issue to deal with effectively. Painful diabetic polyneuropathy is a complex pain condition that occurs with reasonable frequency in the population and it maybe extremely difficult for clinicians to provide patients with effective analgesia. Chronic neuropathic pain may occur in approximately one of every four diabetic patie…
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Sleep-Disordered Breathing in Epilepsy: Epidemiology, Mechanisms and Treatment
Epilepsy is a group of neurological conditions in which there is a pathological and enduring predisposition to generate recurrentrnseizures. Evidence over the last few decades suggests that epilepsy may be associated with increased sleep-disordered breathing,rnwhich may contribute towards sleep fragmentation, daytime somnolence, reduced seizure control, and cardiovascular-relatedrnmorbidity and…
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Single dose pharmacokinetic equivalence study of two gabapentin preparations …
The geometric mean ratios (90% confidence interval) of the test drug/reference drug for gabapentin were 103.15% (90.38%–117.72%) for AUCt , 103.53% (90.78%–118.07%) for AUCinf, and 108.06% (96.32%–121.24%) for Cmax. The differences in tmax and t1/2 values between the test and reference drug products for gabapentin were not statistically significant. Light-headedness, nausea, and headache …
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Comparative Efficacy and Safety of Six Antidepressants and Anticonvulsants in…
Anticonvulsants and antidepressants are mostly used in management of painful diabetic neuropathy (PDN). However there are few direct comparisons between drugs of these classes, making evidence-based decision-making in the treatment of painful diabetic neuropathy
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EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 re…
Most large RCTs included patients with diabetic polyneuropathies and postherpetic neuralgia, while an increasing number of smaller studies explored other conditions. Drugs generally have similar efficacy in various conditions, except in trigeminal neuralgia, chronic radiculopathy and HIV neuropathy, with level A evidence in support of tricyclic antidepressants (TCA), pregabalin, gabapentin, tr…
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Sepsis
Sepsis is a clinical syndrome that requires prompt recognition andrncontrol in order to optimize clinical outcomes in patients. It is very relevantrnto surgical practice, as it can affect perioperative patients andrnthose recovering on surgical wards. A working knowledge of sepsisrnis essential to any medical or surgical practitioner, and here werncover the topic with relevance to surgery and t…
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Type 2 Myocardial Infarction : JACC Review Topic of the Week
Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption; a condition called type 2 myocardial infarction (T2MI). As with any MI subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis. This condition is increasingly diagnosed due to the increasing sensitiv…
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Bendamustine plus rituximab versus CHOP plus rituximab as fi rst-line treatme…
Rituximab plus chemotherapy, most often CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), is the fi rst-line standard of care for patients with advanced indolent lymphoma, and for elderly patients with mantle-cell lymphoma. Bendamustine plus rituximab is eff ctive for relapsed or refractory disease. We compared bendamustine plus rituximab with CHOP plus rituximab (R-CHOP) as fi…
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Ovarian cancer is predominantly a disease of older, postmenopausal women with…
This randomized, noninferiority (NI), global, phase 3 study evaluated the efficacy and safety ofbendamustineplusrituximab(BR) vs a standard rituximab-chemotherapy regimen (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP] or rituximab plus cyclophosphamide, vincristine, and prednisone [R-CVP]) for treatmentnaive patients with indolent non-Hodgkin’s lymphoma or…
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