Photoageing: mechanism, prevention and therapy

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Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up

Purpose Regular sunscreen use prevents cutaneous squamous cell carcinoma long term, but the effect on melanoma is highly controversial. We evaluated whether long-term application of sunscreen decreases risk of cutaneous melanoma

Evaluation and management of variceal bleeding

Acute variceal bleeding is one of the most fatal complications of cirrhosis and is responsible for about one-third of cirrhosis-related deaths.Therefore,every effort should be made to emergently resuscitate the patients,start pharma-cotherapy as soon as possible and do endoscopic therapy in a timely manner. Despite there cent advances in treatment, mortality rate is still high.We provide a comp…

Radiation Colitis and Proctitis

Radiation therapy is commonly utilized as a major component in the treatment of pelvic malignancy. Unfortunately, secondary toxicity to the lower gastrointestinal tract can occur. This most commonly affects the rectum, although injuries to the colon and small intestine are not uncommon. The presentation can be acute or chronic, and different mechanisms are responsible for each. Symptomatology i…

Evaluasi Penggunaan Antibiotik dan Profil Kuman pada Seksio Sesarea di Rumah …

Infeksi Luka Operasi (ILO) adalah salah satu komplikasi pembedahan yang paling umum terjadi di dunia, terutama di negara berkembang. Penggunaan antibiotik profilaksis sebelum operasi yang tepat dapat mengurangi ILO. Penelitian ini bertujuan untuk mengetahui profil penggunaan antibiotik dan kesesuaian penggunaan antibiotik pada seksio sesarea dengan peta kuman rumah sakit, Pedoman Penggunaan Ant…

Typhoid fever: issues in laboratory detection, treatment options & concerns i…

Multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi (resistant to ampicillin, chloramphenicol and cotrimoxazole), was significantly reduced with the increased usage of fluoroquinolones and azithromycin. This has led to declining multidrug resistance rates in Indiawith increasing ciprofloxacin nonsusceptibility rates and clinical failures due to azithromycin. However, for the …

Pharmacokinetic Profile of Levofloxacin following Once-Daily 500-Milligram Or…

The pharmacokinetics of once-daily oral levofloxacin (study A) or intravenous levofloxacin (study B) in 40 healthy male volunteers were investigated in two separate randomized, double-blind, parallel-design, placebocontrolled studies. Levofloxacin at 500 mg or placebo was administered orally or intravenously as a single dose on day 1; daily oral or intravenous dosing resumed on days 4 to 10. I…

A Multicenter, Randomized Study Comparing the Efficacy and Safety of Intraven…

Five hundred ninety patients were enrolled in a prospective, multicenter, randomized trial comparing the efficacy and safety of 7 to 14 days of levofloxacin treatment with that of ceftriaxone and/or cefuroxime axetil in the management of community-acquired pneumonia in adults. Patients received either intravenous and/or oral levofloxacin (500 mg once daily) or the comparative agents, parentera…

Comparative Pharmacokinetics of Ciprofloxacin, Gatifloxacin, Grepafloxacin, L…

In an open, randomized, six-period crossover study, the pharmacokinetics of ciprofloxacin, gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin were compared after a single oral dose in 12 healthy volunteers (6 men and 6 women). The volunteers received 250 mg of ciprofloxacin, 400 mg of gatifloxacin, 600 mg of grepafloxacin, 500 mg of levofloxacin, 400 mg of moxifloxacin,…

Oral bioavailability study of 500mg Levofloxacin in healthy volunteers: a pha…

Penelitian ini dilakukan untuk mengetahui apakah bioavailabilitas tablet levofloksasin 500 mg yang diproduksi oleh PT. Dexa Medica (Volequin) sebanding dengan bioavailabilitas produk pembanding. Parameter farmakokinetik yang dinilai dalam studi ini ialah kadar puncak (Cmax), waktu untuk mencapai kadar puncak (tmax), waktu paruh eliminasi (t1/2), luas daerah di bawah kur…