Systemic Lupus Erythematosus : Epidemiology, Pathophysiology, Manifestations,…

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder, characterized by production of autoantibodies directed against nuclear and cytoplasmic antigens, which may affect several different organs, with a plethora of different clinical and immunologic abnormalities, characterized by a relapsing and remitting clinical course

Zinc and immune function: the biological basis of altered resistance to infec…

Zinc is known to play a central role in the immune system, and zinc-deficient persons experience increased susceptibility to a variety of pathogens. The immunologic mechanisms whereby zinc modulates increased susceptibility to infection have been studied for several decades. It is clear that zinc affects multiple aspects of the immune system, from the barrier of the skin to gene regulation with…

The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmon…

N-acetylcysteine (NAC) is an antioxidant and anti-inflammatory. Its effects on chronic obstructive pulmonary (COPD) outcomes, including exacerbation of and changes in lung function parameters, are controversial. To investigate the effects of NAC on COPD exacerbation and changes in lung function parameters in patients with COPD. A meta-analysis of randomized controlled trials retrieved from Pub…

Efek proteksi kombinasi parasetamol dan N-Asetilsistein terhadap kerusakan se…

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Accidental paracetamol poisoning

A 45-year-old woman was referred to the Victorian Liver Transplant Unit with acute liver failure following the use of paracetamol at a therapeutic dose during prolonged fasting. Eight weeks previously, the patient had ndergone total abdominal hysterectomy for symptomatic uterine fibroids. Seven weeks after surgery, she was readmitted to hospital with subacute bowel obstruction secondary to adh…

Cyclophosphamide versus methylprednisolone for treating neuropsychiatric invo…

Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is complex and it is an important cause ofmorbidity andmortality. Management of nervous system manifestations of SLE remains unsatisfactory. This is an update of a Cochrane review first published in 2000 and previously updated in 2006

2017 American College of Rheumatology Guideline for the Prevention and Treatm…

Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient. The ACR considers adherence to the recommendations within this guideline to be voluntary, with the ultimate determination regarding their application to be made by the phys…

Intratympanic dexamethasone injection vs methylprednisolone for the treatment…

During the past years various drugs have been used for sudden sensorineural hearing loss (SSNHL) treatment including steroids that are shown to be beneficial. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). Despite the use of dexamethasone and methylprednisolone as the traditional treatments, there …

Immunopathogenesis and treatment of cytokine storm in COVID-19

Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine storm refers to a set of clinical conditions caused by excessive immune reactions and has been recognized as a leading cause of severe COVID-19. While comparisons have been made between COVID-19 cytokine storm and other kinds of cy…

Safety and efficacy of manual small incision cataract surgery for brunescent …

To evaluate the safety, visual outcome and complications of manual small incision cataract surgery (MSICS) in the treatment of patients with brunescent and black cataract (BBC).