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Benefit-Risk Assessment of Rosuvastatin 10 to 40 Milligrams
The aim of this article is to examine the benefit-risk profile of rosuvastatin at doses of 10 to 40 mg. In dyslipidemic patients, rosuvastatin produced markedly greater reductions in low-density lipoprotein (LDL) cholesterol and equivalent or greater improvements in various lipid measures, including high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, and triglycerides when compared…
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Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin …
Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 mg) and atorvastatin (20 mg) in high-risk patients with hypercholesterolemia
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Comparison of the Efficacy and Safety of Rosuvastatin Versus Atorvastatin, Si…
The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose ranges for reduction of lowdensity lipoprotein (LDL) cholesterol. Secondary objectives included comparing rosuvastatin with comparators for other lipid modifications and achievement of National Cholesterol Educati…
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Comparison of Efficacy and Safety of Rosuvastatin Versus Atorvastatin in Afri…
The lipid-modifying effects of statin therapy in hypercholesterolemic African-Americans have not been well characterized. This study compared the efficacy and safety of rosuvastatin and atorvastatin treatment for 6 weeks in hypercholesterolemic African-American adults. In the African American Rosuvastatin Investigation of Efficacy and Safety (ARIES) trial (4522US/0002), 774 adult African-Americ…
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Management of Acute Asthma Exacerbations
Asthma exacerbations can be classified as mild, moderate, severe, or life threatening. Criteria for exacerbation severity are based on symptoms and physical examination parameters, as well as lung function and oxygen saturation. In patients with a peak expiratory flow of 50 to 79 percent of their personal best, up to two treatments of two to six inhalations of short-acting beta2 agonists 20 min…
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Managing Asthma Exacerbations in the Emergency Department Summary of the Nati…
This article summarizes the recommendations regarding the management of asthma exacerbations presented in the Expert Panel Report 3 (EPR3) (1). The evidence supporting these recommendations can be found in the report itself. All of the recommendations in this article are strong recommendations, unless indicated by the term ‘‘conditional.’’
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Diagnosis and Management of Rheumatoid Arthritis : A Review
Rheumatoid arthritis (RA) occurs in about 5 per 1000 people and can lead to severe joint damage and disability. Significant progress has been made over the past 2 decades regarding understanding of disease pathophysiology, optimal outcome measures, and effective treatment strategies, including the recognition of the importance of diagnosing and treating RA early.
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Immunotherapy in Lung Cancer
Lung cancer is the leading cause of cancer-related mortality in the United States.1 Non–small cell lung cancer (NSCLC) comprises approximately 85% of all lung cancer cases.2 Among patients with NSCLC, approximately 40% present with stage IV disease. 3 Although targeted therapy has been associated with a significant benefit in patients harboring aberrations in epidermal growth factor receptor…
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Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Recent medical advances have improved the understanding, diagnosis, and treatment of paraneoplastic syndromes. These disorders arise from tumor secretion of hormones, peptides, or cytokines or from immune cross-reactivity between malignant and normal tissues. Paraneoplastic syndromes may affect diverse organ systems, most notably the endocrine, neurologic, dermatologic, rheumatologic, and hemat…
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Assessment of Quality of Life (QoL) in Systemic Lupus Erythematosus Patients …
One hundred sixty-four SLE patients were recruited for this study. Demographic information; clinical parameters; disease activity, as evaluated by the Systemic Lupus Erythematosus Disease Activity Index; and organ damage, as assessed by the Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index, were reported. Quality of life was assessed with a qualit…
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