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Sepsis
Sepsis is a clinical syndrome that requires prompt recognition andrncontrol in order to optimize clinical outcomes in patients. It is very relevantrnto surgical practice, as it can affect perioperative patients andrnthose recovering on surgical wards. A working knowledge of sepsisrnis essential to any medical or surgical practitioner, and here werncover the topic with relevance to surgery and t…
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Type 2 Myocardial Infarction : JACC Review Topic of the Week
Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption; a condition called type 2 myocardial infarction (T2MI). As with any MI subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis. This condition is increasingly diagnosed due to the increasing sensitiv…
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Bendamustine plus rituximab versus CHOP plus rituximab as fi rst-line treatme…
Rituximab plus chemotherapy, most often CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), is the fi rst-line standard of care for patients with advanced indolent lymphoma, and for elderly patients with mantle-cell lymphoma. Bendamustine plus rituximab is eff ctive for relapsed or refractory disease. We compared bendamustine plus rituximab with CHOP plus rituximab (R-CHOP) as fi…
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Ovarian cancer is predominantly a disease of older, postmenopausal women with…
This randomized, noninferiority (NI), global, phase 3 study evaluated the efficacy and safety ofbendamustineplusrituximab(BR) vs a standard rituximab-chemotherapy regimen (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone [R-CHOP] or rituximab plus cyclophosphamide, vincristine, and prednisone [R-CVP]) for treatmentnaive patients with indolent non-Hodgkin’s lymphoma or…
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Complete blood count parameters in peripheral arterial disease
The groups were statistically similar with regards to baseline clinical and demographic features. The values of C-reactive protein, white blood cell and neutrophil-to-lymphocyte ratio values were found to be statistically significantly higher in study group versus control group, but none of them were considered as an independent predictor of peripheral arterial disease according to multivar…
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Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a chronic atherosclerotic process that causes narrowing of the peripheral arterial vasculature, predominantly of the lower limbs. It has an estimated worldwide prevalence of up to 10%, increasing to nearly 30% in patients more than 50 years of age.1 Critical limb ischemia (CLI), the most severe manifestation of the disease, can result in limb loss, or even …
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Comparison of Antibiotic Effect and Corneal Epithelial Toxicity of Levofloxac…
To compare the bacterial susceptibility and corneal epithelial toxicity of levofloxacin and moxifloxacin in the human corneal epithelial cells (HCECs).
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Long-chain omega-3 fatty acids an the brain: a review of the independent and …
Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and represent a potential treatment for a variety of neurodegenerative and neurological disorders. However, traditionally there has been a lack of discrimination between the different omega-3 PUFAs and effects have been broadly accredited to the series as a whole. Evidence for unique effects of eicosapentaenoic acid …
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Supplementation of DHA but not DHA with arachidonic acid during pregnancy and…
DHA and arachidonic acid (AA) are important for neurodevelopment. A traditional neonatal neurological examination and the evaluation of general movement quality are sensitive techniques for assessing neurodevelopment in young infants. Mildly abnormal general movements at 3 months have been associated with a non-optimal current brain condition. We investigated whether supplementation of DHA duri…
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Factors That Influence the Immune Response to Vaccination
There is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans. These include intrinsic host factors (such as age, sex, genetics, and comorbidities), perinatal factors (such as gestational age, birth weight, …
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