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Intravenous esomeprazole 40 mg vs. intravenous lansoprazole 30 mg for control…
On days 1 and 5, intragastric pH was >4.0 significantly longer with esomeprazole than lansoprazole (least-squares means: day 1, 40.0% vs. 33.6%; day 5, 61.9% vs. 45.4%; both P < 0.0001). During the first 4 h of pH monitoring, intragastric pH was >4.0 significantly longer on days 1 and 5 with esomeprazole than lansoprazole (P < 0.0001). Kaplan–Meier estimates of median hours to stable pH >4.…
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Esomeprazole 40 mg i.v. provides faster and more effective intragastric acid …
Once-daily dosing with esomeprazole 40 mg intravenously provides faster and more pronounced intragastric acid control than pantoprazole 40 mg intravenously
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An extended 36-week oral esomeprazole improved long-term recurrent peptic ulc…
Patients with Rockall scores ≥6 have an increased risk of long-term peptic ulcer rebleeding. This study was aimed toward investigating whether an extended course of oral esomeprazole up to 1 year decreased ulcer rebleeding in such patients.
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Pharmacokinetics of Esomeprazole in Critically Ill Patients
Esomeprazole, a potent proton pump inhibitor (PPI), is widely used for the prevention of stress ulcers in intensive care unit (ICU) patients.
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Study on the preventive effect of intravenous esomeprazole in the management …
This retrospective study investigated the preventive effect of intravenous esomeprazole (IVEO) in the prevention of nonvarices upper gastrointestinal bleeding (NUGIB). This study enrolled 130 patients with NUGIB and all of them underwent successful endoscopic hemostasis, of which 65 cases received routine management and IVEO (Group A) and the other 65 cases received routine management alone (G…
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Pharmacological Treatment of Diabetic Neuropathic Pain
Neuropathic pain continues to be a difficult and challenging clinical issue to deal with effectively. Painful diabetic polyneuropathy is a complex pain condition that occurs with reasonable frequency in the population and it maybe extremely difficult for clinicians to provide patients with effective analgesia. Chronic neuropathic pain may occur in approximately one of every four diabetic patie…
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Sleep-Disordered Breathing in Epilepsy: Epidemiology, Mechanisms and Treatment
Epilepsy is a group of neurological conditions in which there is a pathological and enduring predisposition to generate recurrentrnseizures. Evidence over the last few decades suggests that epilepsy may be associated with increased sleep-disordered breathing,rnwhich may contribute towards sleep fragmentation, daytime somnolence, reduced seizure control, and cardiovascular-relatedrnmorbidity and…
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Single dose pharmacokinetic equivalence study of two gabapentin preparations …
The geometric mean ratios (90% confidence interval) of the test drug/reference drug for gabapentin were 103.15% (90.38%–117.72%) for AUCt , 103.53% (90.78%–118.07%) for AUCinf, and 108.06% (96.32%–121.24%) for Cmax. The differences in tmax and t1/2 values between the test and reference drug products for gabapentin were not statistically significant. Light-headedness, nausea, and headache …
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Comparative Efficacy and Safety of Six Antidepressants and Anticonvulsants in…
Anticonvulsants and antidepressants are mostly used in management of painful diabetic neuropathy (PDN). However there are few direct comparisons between drugs of these classes, making evidence-based decision-making in the treatment of painful diabetic neuropathy
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EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 re…
Most large RCTs included patients with diabetic polyneuropathies and postherpetic neuralgia, while an increasing number of smaller studies explored other conditions. Drugs generally have similar efficacy in various conditions, except in trigeminal neuralgia, chronic radiculopathy and HIV neuropathy, with level A evidence in support of tricyclic antidepressants (TCA), pregabalin, gabapentin, tr…
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