Management of traumatic perilymph fistula with endoscopic techniques

These images relate to a 13-year-old boy who sustained a traumatic perilymph fistula (tPLF) resulting from a skateboarding accident.

Safety of New Oral Anticoagulants for Patients with Chronic Kidney Disease

In daily practice, chemical substances called “direct oral anticoagulants” or DOACs are more convenient to administer when set beside vitamin K antagonists (VKA) due to improved pharmacologic properties, fewer drug interactions and rapid onset of action. The objective of this review was to assess whether DOACs are the alternative for VKA in subjects with mild-to-moderate chronic kidney d…

Efficacy and safety of statin therapy in older people: a meta-analysis of ind…

Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range ofrnindividuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysisrnof data from all large statin trials to compare the effects of statin therapy at different ages.

Variant ECG pattern associated with acute proximal left anterior descending o…

Primary percutaneous coronary intervention is the gold-standard treatment for acute coronary artery occlusion. This is primarily diagnosed by ST segment elevation on an ECG accompanying ischaemic-sounding chest pain.

Anticoagulation in CKD and ESRD

In this review we discuss the evolving literature of anticoagulation in the context of the nephrology patient. Whereas CKDrnpatients with atrial fibrillation, should be anticoagulated, the benefit of anticoagulation for those on dialysis remains controversialrndue to an increased risk of bleeding. The availability of direct oral anticoagulants offers new options for thosernwith CKD. Until studi…

Probiotics: an update on mechanisms of action and clinical applications

Probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. The most predominant species that have been used as probiotic include Lactobacilli and bifidobacteria. Proper administration of probiotics could be efficient in the treatment of various disorders. However; their mechanism of action is poorly understood

Scalp Block for Burr Holle Evacuation of Subdural Hematoma:rnA Series of Seve…

A scalp block is a good perioperative and postoperative anesthesia/rnanalgesia method that has become widespread and preferred by many anesthesiologists.rnMaterial and Method: The present report presented sevenrnpatients, who underwent scalp block due to the evacuation of a subduralrnhematoma. The demographic features of the patients, sedative agents administered,rnand local anesthetic agents a…

Knowledge Sharing Session - BERANDA: BElajar GRAmmar BareNg WaNDA Vol. 1

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Effect of Chloramphenicol and Thiamphenicol on the In Vitro Colony-forming Cell

STRONG EVIDENCE HAS been provided to indicate that chloramphenicol-(CAP) induced reversible bone marrow suppression results from inhibition of mitochondrial protein synthesis and consequent mitochondrial injury. ı Suppression of ferrochelatase activity, a mitochondrial-membraneassociated enzyme, with a block in the last step of heme synthesis has been suggested as a basis for the apparent vuln…

PHARMACOKINETIC STUDIES ON THIAMPHENICOL IN GOATS

Thiamphenicol is a semisynthetic structural analogue of chloramphenicol (CAP)(Sutter and Finegold, 1976). Chemically, it is D-d-threo-2-dichloro acetamido-l-(4-methylsulfonyl)-phenyl-l, 3-propanediol and has been derived by replacing the p-nitrophenol group of chloramphenicol by methylsulfonyl moietv