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Coronavirus disease-2019: is fever an adequate screening for the returning tr…
On Thursday, 30 January 2020, World Health Organization declared Coronavirus disease-2019 (COVID-2019) a Public Health Emergency of International Concern. Since its identification in late December 2019 in Wuhan, Hubei Province, People’s Republic of China, the number of cases imported into other countries is increasing, and the epidemiological map is changing rapidly. On the other hand, bod…
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Mechanical Ventilation: Settings and Basic Modes
Mechanical ventilation is a lifesaving tool utilized in the intensive care unit, during surgical procedures requiring general anesthesia, and in long-term acute care settings to assist patients who require additional respiratory support. Invasive mechanical ventilation requires an endotracheal tube that is connected to a ventilator, whereas non-invasive ventilation delivers oxygen through a …
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Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea it…
DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflammatory properties. The current clinical study evaluated the efficacy and safety of DLBS1442 in alleviating symptoms of premenstrual syndrome and primary dysmenorrhea
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Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological ef…
Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macrocarpa especially in Asia reflects the usage of diverse extraction techniques, particularly modern a…
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Effectivity and safety of mahkota dewa fruit extract compared to meloxicam (p…
Osteoarthritis (OA) is the most common musculoskeletal disease. World Health Organization (WHO) estimates that 10% of the aged over 60 year population have this disease. The aim of OA treatment is to reduce pain, which is the most OA patients chief complaint. People in Indonesia are very interested in use of herbal therapies from original traditional plant to treat pain now, one of the tradit…
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Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined…
The aim of this paper is to evaluate the efficacy and safety of DLBS3233, a novel bioactive fraction derived from Cinnamomum burmanii and Lagerstroemia speciosa, in improving insulin resistance and preserving β-cell performance in patients with impaired glucose tolerance (IGT).
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DLBS3233 extract, a novel insulin sensitizer with negligible risk of hypoglyc…
DLBS3233 is a standardized extract combination of two Indonesian herbals (Lagerstroemia speciosa L. and Cinnamomum burmanii L.) developed by a patented extraction-technology. DLBS3233 has been proven pre-clinically to have a glucose lowering activity. This Phase 1 clinical study evaluated the safety of DLBS3233 in comparison with the negative-control and pioglitazone 30 mg (active control) in h…
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Mechanisms Involved in the Relationship between Vitamin D and Insulin Resista…
Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extraskeletal activity. In this context, vitamin D seems to be involved in infections autoimmune diseases, cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D) levels appe…
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Vitamin D supplementation and incident preeclampsia: A systematic review and …
Maternal vitamin D deficiency has been associated with an increased risk for preeclampsia. Despite this, the current evidence regarding the efficacy of vitamin D supplementation in preventing preeclampsia is controversial. To assess the impact of vitamin D supplementation on the risk of preeclampsia, we performed a systematic review of the literature and a meta-analysis of the available random…
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Role of Vitamin D in the Metabolic Syndrome
The prevalence of hypovitaminosis D has risen in developed countries over the past few years in association with lifestyle changes and an increase in unhealthy habits. Vitamin D deficiency has been implicated in various diseases, including metabolic syndrome (MetS), which is clinically defined by a set of metabolic and vascular disorders. The objective of this study was to review scientific…
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