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The Prognostic Significance of Carotid Intima-Media Thickness in Patients Who…
Objectives：Increased carotid intima-media thickness (IMT) is known to be associated with adverse cardiovascular events in the patients with risk factors or established atherosclerosis. However, the prognostic importance of carotid IMT is uncertain in the patients who underwent percutaneous coronary intervention (PCI). We sought to evaluate the association of carotid IMT with major adverse …
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Association of increased carotid intima-media thickness with the extent of co…
To investigate (a) the relation between intima-media thickness (IMT) in carotid arteries and the extent of coronary artery disease (CAD); and (b) whether IMT is predictive of coronary atherosclerosis. The coexistence of severe extracranial atherosclerosis in patients with CAD was also analysed
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Sclerostin
TheWnt signaling pathway demonstrates a complex network of proteins well known for their roles in embryogenesis but also involving normal physiologic processes of bone formation in response to loading and unloading
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Sclerostin: Current Knowledge and Future Perspectives
In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts.
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Management of traumatic perilymph fistula with endoscopic techniques
These images relate to a 13-year-old boy who sustained a traumatic perilymph fistula (tPLF) resulting from a skateboarding accident.
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Safety of New Oral Anticoagulants for Patients with Chronic Kidney Disease
In daily practice, chemical substances called “direct oral anticoagulants” or DOACs are more convenient to administer when set beside vitamin K antagonists (VKA) due to improved pharmacologic properties, fewer drug interactions and rapid onset of action. The objective of this review was to assess whether DOACs are the alternative for VKA in subjects with mild-to-moderate chronic kidney d…
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Efficacy and safety of statin therapy in older people: a meta-analysis of ind…
Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range ofrnindividuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysisrnof data from all large statin trials to compare the effects of statin therapy at different ages.
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Variant ECG pattern associated with acute proximal left anterior descending o…
Primary percutaneous coronary intervention is the gold-standard treatment for acute coronary artery occlusion. This is primarily diagnosed by ST segment elevation on an ECG accompanying ischaemic-sounding chest pain.
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Anticoagulation in CKD and ESRD
In this review we discuss the evolving literature of anticoagulation in the context of the nephrology patient. Whereas CKDrnpatients with atrial fibrillation, should be anticoagulated, the benefit of anticoagulation for those on dialysis remains controversialrndue to an increased risk of bleeding. The availability of direct oral anticoagulants offers new options for thosernwith CKD. Until studi…
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Probiotics: an update on mechanisms of action and clinical applications
Probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. The most predominant species that have been used as probiotic include Lactobacilli and bifidobacteria. Proper administration of probiotics could be efficient in the treatment of various disorders. However; their mechanism of action is poorly understood
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