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Editorial : How Best to Resuscitate Patients With Septic Shock?
What is the best approach for resuscitation of a patien twit hseptic shock? Despite considerable investigation over several decades, this important question still has no clear answer. There is agreement that resuscitation should proceed quickly, for the longer the delay, the greater the physiologic stress and endorgan injury. However, treatment options are principally intravenous fluids and va…
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BOOK REVIEW : Disease-related Malnutrition: An Evidence-based Approach to Tre…
Whoever cares for cost–benefit and cost–effectiveness of treatments must use this book; its focus is to establish, share with the readers and entice them to practice, adequate evidence-base for the provision of nutritional therapy
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Dynamic Changes in the ST-T Segment During Sleep in Ischemic Heart Disease
The electrocardiographic pattern during sleep was recorded in 140 patients with chronic ischemic heart disease by the Holter continuous recording system. Among the 97 patients who had fixed abnormal ST-T changes during the day, the severity of the pathologic pattern decreased during sleep in 39, remained unchanged in 35 and became more marked in 23 patients. The deterioration of ST-T changes i…
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Practical Genetics : Tuberous sclerosis
Tuberous sclerosis is a serious inherited disease which poses major challenges for affected families and those caring for them. Identification of the genes causing the condition and study of their protein products has shed light on the pathogenesis of the disease and provided valuable new information about signalling pathways regulating protein synthesis and cell growth. There is now the exciti…
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Tuberous sclerosis
Tuberous sclerosis is an autosomal dominant multisystemic genetic condition that can affect many organs: brain, skin, eye, heart, lungs and the kidney. It affects one in 7 to 8,000 people. Its main complications involve the nervous system (convulsions, intracranial hypertension), the kidneys (rupture of cysts and angiomyolipomas) and the lungs of adult females (rupture of bullae with lymphangio…
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Tuberous Sclerosis
Tuberous sclerosis or Tuberous Sclerosis Complex (TSC) is a genetic disorder characterized by the growth of numerous benign tumours in many parts of the body caused by mutations on either of two genes, TSC1 and TSC2. The case of a 31 year old female who fulfilled 8 major criteria of Tuberous Sclerosis Complex is reported. Multiple research work projects are being carried out on this disease, u…
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Penatalaksanaan Fisioterapi Pada Kondisi Cervical Root Syndrome et causa Spon…
Cervical root syndrome et causa spondylosis cervical is a condition caused by degeneration of factors that occur in the discus intervertebral C1-C7, due to the emphasis on the spinal cord in the neck. Problems on cervical spondylosis is often the case, namely: pain, limitation of motion, muscle spasm, and decreased functional ability. To provide an effective and efficient treatment, then was e…
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Neck pain (cervical syndrome)
Pain can radiate in an imprecisely defi ned way into the back of the head, forehead, neck, shoulders and upper arms.
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Pasireotide (SOM230) Prevents Sulfonylurea-induced Hypoglycemia in Rats
Persistent hypoglycemia is a serious condition that is frequently reported in patients undergoing sulfonylurea treatment, often necessitating hospitalization in the event of overdose. Somatostatin is a regulatory hormone with a broad range of physiological actions that include the inhibition of insulin and glucagon secretion, predominantly via activation of the somatostatin receptor subtypes …
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Octreotide for hypoglycemia caused by sulfonylurea and DPP-4 inhibitor
We describe a type 2 diabetes patient with persistent hypoglycemia caused by sulfonylurea misuse on top of a DPP-4 inhibitor. Hyperinsulinemia was exaggerated by dextrose administration, but was successfully treated with octreotide. Since many patients are currently treated with DPP-4 inhibitors, the importance of octreotide has been increasing. For refractory sulfonylurea-induced hypoglyce…
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