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Strategies to increase nitric oxide signalling in cardiovascular disease
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central nervous systems, and crucial steps in the regulation of NO bioavailability in health and disease are well characterized. Although early approaches to therapeutically modulate NO bioavailability failed in clinical trials, an enhanced understanding of fundamental subcellular signalling has enabled a range of …
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Rheumatoid arthritis in adults: management
The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals and practitioners are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or the people using their service
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2015 American College of Rheumatology Guideline for the Treatment of Rheumato…
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient. The ACR considers adherence to the recommendations within this guideline to be voluntary, with the ultimate determination regarding their application to be made by the phys…
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Tailoring Natural Killer cell immunotherapy to the tumour microenvironment
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have…
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THE CONCEPTUAL AND CLINICAL PROBLEMS OF PARANEOPLASTIC SYNDROME IN ONCOLOGY A…
Symptomatology of oncological diseases consists not only of local symptoms caused by the primary malignancy or its metastases, but also by general systemic signs that are not directly connected with the tumor. These symptoms are mostly associated with auto-immunity or endocrine influences. In many cases, the source of paraneoplastic syndromes (PNS) is unknown. Nearly 15% of on-cological patient…
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Cancer Drug Toxicities and Anaesthesia
Cancer is now overtaking cardiac disease as the most common cause of death in Western societies. Perhaps the main reason for this is increased life expectancy at birth. However, elsewhere, cancer is also rising in incidence, due in no small part to chronic infections such as viral hepatitis. Given improved survival with aggressive and modern treatments, surgery is becoming more important in the…
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Anesthetics impact on cancer recurrence: What do we know?
Surgery is an important component of treatment in cancer patients. However, surgical stress, anesthesia, and perioperative analgesia interfere with the host immune defense mechanisms and may contribute to metastatic dissemination of malignant tumors and cancer progression. Little is known about the effects of anesthesia on tumor recurrence. In vivo studies and clinical data show some evidence t…
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Pharmacokinetics of levobupivacaine with epinephrine in transversus abdominis…
Transversus abdominis plane block is increasingly used for post-Caesarean section analgesia. Cases of toxicity and the limited pharmacokinetic information during pregnancy motivated this study. The objective of the study was to characterise and compare the pharmacokinetics of levobupivacaine with epinephrine in tranversus abdominis plane block, in post-Caesarean section patients and healthy vol…
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Wound Management
Clinicians should be familiar with the principles of wound management, including repair methods, risks for infection, tetanus prophylaxis, and appropriate use of antibiotics and diagnostic studies.
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Multifactorial Approaches for Correction of the Drooping Tip of a Long Nose i…
A long nose with a drooping tip is a major aesthetic problem. It creates a negative and aged appearance and looks worse when smiling. In order to rectify this problem, the underlying anatomical causes should be understood and corrected simultaneously to optimize surgical outcomes. The causes of a drooping tip of a long nose are generally classified into two mechanisms.
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