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Impact of age on the diagnostic performances and cut-offs of APRI and FIB-4 f…
The APRI AUROC in patients aged
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AST to platelet ratio index (APRI) for the noninvasive evaluation of liver fi…
Liver biopsy is the recognized gold standard for liver fibrosis staging. The aspartate minotransferase to platelet ratio index (APRI) has been proposed as a noninvasive and readily available tool for the assessment of liver fibrosis in chronic hepatitis C (CHC). This study aimed to validate, in a Mexican tertiary health care setting, the diagnostic usefulness of APRI in CHC, nonalcoholic fatty…
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Variceal bleeding in cirrhotic patients
Variceal bleeding is one of the major causes of death in cirrhotic patients. The management during the acute phase and the secondary prophylaxis is well defined. Recent recommendations (2015 Baveno VI expert consensus) are available and should be followed for an optimal management, which must be performed as an emergency in a liver or general intensive-care unit. It is based on the early admini…
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Patient Diagnosis Resource for Radiation Colitis
Your doctor has determined that you have radiation colitis, an inflammation of the colon that occurs as a side effect of cancer radiation therapy to the abdomen or pelvis. The condition can arise from external radiation treatment delivered by a high energy X-ray machine or internal radiation therapy, which is delivered through small implants placed directly into or near the cancerous tumor
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Idiopathic Noncirrhotic Portal Hypertension
Cirrhosis is the most common cause of portal hypertension but a heterogeneous group of clinical entities, collectively referred to as non-cirrhotic portal hypertension (NCPH), can also lead to elevation of the portal venous pressure in the absence of cirrhosis. Common causes of NCPH are nonalcoholic or alcoholic steatohepatitis, primary biliary cholangitis, primary sclerosing cholangitis, conge…
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2018 International Consensus on Cardiopulmonary Resuscitation and Emergency C…
The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the second annual summary of International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations that includes the most recent cardiopulmonary resuscitation science rev…
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Laryngeal framework surgery: current strategies
Laryngeal framework surgery (LFS) is an indispensable surgical approach for the treatment of voice problems. The purpose of this review is to single out some relevant articles published on the topic of LFS from 2015 to mid-2016. Articles referring to injection laryngoplasty (augmentation) are entirely left aside
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A new medical therapy for anemia in thalassemia
In this issue of Blood, Piga et al report results of a phase 2, open label, nonrandomized, uncontrolled dose-finding study evaluating the effects of luspatercept on erythroid maturation and differentiation in adult patients with b-thalassemia.1 A high percentage of patients had an increase in hemoglobin or a reduction in transfusion burden, which helped lay the basis for future randomized trials
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GNAS: A New Nephrogenic Cause of Inappropriate Antidiuresis
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is the mirror image of nephrogenic diabetes insipidus (NDI): in NDI, the kidneys cannot concentrate the urine, whereas in NSIAD, urinary dilution is impaired, independent of the presence or absence of vasopressin. Consequently, patients with NDI are at risk of hypernatremic dehydration, whereas hyponatremia is a typical manifestation …
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Patient Perspectives on the Meaning and Impact of Fatigue in Hemodialysis: A …
Fatigue is a highly prevalent and debilitating symptom in patients on hemodialysis therapy due to the uremic milieu, the hemodialysis treatment itself, and other comorbid conditions. However, fatigue remains underrecognized and the consequences are underappreciated because it may not be visible in clinical settings. This study aims to describe the experience that patients undergoing maintenance…
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