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Alopecia Areata and Down Syndrome: A True Association or a Coincidence
The cause of alopecia areata (AA) is not entirely understood, although a strong genetic basis for this condition has been suggested.[1] Several studies have showed that AA is associated with Down syndrome (DS), implicating that a causative gene for this condition is located on chromosome 21
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P-glycoprotein and its role in drug-drug interactions
Important substrates of P-glycoprotein include calcium channel blockers, cyclosporin, dabigatran etexilate, digoxin, erythromycin, loperamide, protease inhibitors and tacrolimus. Predicting clinically important interactions is difficult because of interindividual differences in drug transport
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Overview of P-glycoprotein inhibitors: a rational outlook
P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resista…
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Potential Benefits of pH 8.8 Alkaline Drinking Water as an Adjunct in the Tre…
Unlike conventional drinking water, pH 8.8 alkaline water instantly denatures pepsin, rendering it permanently inactive. In addition, it has good acid-buffering capacity. Thus, the consumption of alkaline water may have therapeutic benefits for patients with reflux disease
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A Comparison of AlkalineWater and Mediterranean Diet vs Proton Pump Inhibitio…
Laryngopharyngeal reflux (LPR) is a common disorder with protean manifestations in the head and neck. In this retrospective study, we report the efficacy of a wholly dietary approach using alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions compared with that of the traditional treatment approach of proton pump inhibition (PPI) and standard reflux precaut…
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Evaluation of the GeneXpert MTB/RIF Assay for Rapid Diagnosis of Tuberculosis…
Mycobacterium tuberculosis remains one of the most significant causes of death from an infectious agent. The rapid diagnosis of tuberculosis and detection of rifampin (RIF) resistance are essential for early disease management. The GeneXpert MTB/RIF assay is a novel integrated diagnostic device for the diagnosis of tuberculosis and rapid detection of RIF resistance in clinical specimens.
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The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosi…
The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and rifampin resistance (RIF-R) suitable for point-of-care testing. However, it has decreased sensitivity in smear-negative sputum, and false identification of RIF-R occasionally occurs. We developed the Xpert MTB/RIF Ultra assay (Ultra) to improve performance. Ultra and Xpert limits of detection (LOD), dynamic ranges, and R…
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Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampici…
The Xpert MTB/RIF assay is an automated molecular test that has improved the detection of tuberculosis and rifampicin resistance, but its sensitivity is inadequate in patients with paucibacillary disease or HIV. Xpert MTB/RIF Ultra (Xpert Ultra) was developed to overcome this limitation. We compared the diagnostic performance of Xpert Ultra with that of Xpert for detection of tuberculosis and…
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Stem cell therapies for liver failures and cirrhosis
Liver failure and cirrhosis occur as a result of a variety of chronic hepatic injuries. They display sequential and overlapping severe pathogenic processes that include severe inflammation, hepatocyte necrosis, and fibrosis/cirrhosis, and carry a high mortality rate
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The role of nitric oxide in cardiovascular diseases
Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). NO plays an important role in the protection against the onset and progression of cardiovascular disease. Cardiovascular disease is associated with a number of different disorders including h…
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