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A common monitoring framework for ending preventable maternal mortality, 2015…
While global maternal mortality declined 44 % between 1990 and 2015, the majority of countries fell short of attaining Millennium Development Goal targets. The Sustainable Development Goals (SDGs), adopted in late 2015, include a target to reduce national maternal mortality ratios (MMR) to achieve a global average of 70 per 100,000 live births by 2030. A comprehensive paper outlining Strateg…
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Premarital Health Counseling: A Must
Premarital Health Counseling (PMHC) is emerging as a growing trend worldwide. The couples are provided with accurate and unbiased information and assistance, who are planning to get marry with the aim of screening, educating, and counseling about nutritional disorders, communicable diseases, medical conditions, hereditary/genetic disorders, and guiding for a healthy pregnancy. Premarital scr…
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Impact of Baseline Bleeding Risk on Efficacy and Safety of Ticagrelor versus …
Among the 20,816 eligible PCI patients who were included in this study, there were 1578 and 779 patients in the clopidogrel and ticagrelor groups, respectively, after PSM, their clinical parameters were well matched. Patients receiving ticagrelor showed comparable NACE risk compared with those treated by clopidogrel (5.3% vs. 5.1%, P = 0.842). Furthermore, ticagrelor might reduce the MACCE ris…
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Ketamine as a Rapid Sequence Induction Agent in the Trauma Population: A Syst…
The choice of drug used to facilitate endotracheal intubation in trauma patients during rapid sequence induction (RSI) may have an impact on survival. Ketamine is commonly used in the hemodynamically unstable trauma patient although it has been associated with side effects. This review sought to investigate whether ketamine should be preferred over other induction agents for RSI in trauma pati…
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Pharmacotherapy of Chronic Hepatitis B with Entecavir
Actually three nucleotide/nucleoside analogues are used for chronic hepatitis B: lamivudine, adefovir dipivoxil, entecavir and telbivudine. Lamivudine and adefovir are advantageous for oral administration and safety, but they induce a sustained response after withdrawal of therapy in only a minority of patients. Telbivudine is a new drug and further studies are need to evaluate its real effi…
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The role of entecavir in the treatment of chronic hepatitis B
Entecavir (ETV) is a potent and selective inhibitor of hepatitis B virus replication. In HBeAg-positive and HBeAg-negative lamivudine-naïve patients with chronic hepatitis B (CHB), treatment with ETV at a dose of 0.5 mg daily is associated with a more potent viral suppression, a higher rate of biochemical remission and a greater improvement of liver histology compared to Lamivudine (LAM).
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Anaemia in kidney disease: harnessing hypoxia responses for therapy
Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment. Hypoxia-inducible factor (HIF)‑2 is a key regulator of erythropoiesis and iron metabolism. HIF‑2 is activated by hypoxic conditions and controls the p…
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Pathophysiology of renal anaemia
Anaemia remains a prominent feature of chronic kidney disease (CKD). The prevalence is inversely correlated with kidney function, and the vast majority of patients with CKD Stage 5 develop anaemia [
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Uji Klinik Buta Ganda Perbedaan Profil Perdarahan Dan Outcome Klinis Pasien S…
DLBS1033 adalah enzim protease fibrinolitik yang bekerja menghidrolisis fibrin atau fibrinogen dan menstimulasi plasminogen menjadi plasmin. Plasminogen activator (e-PA) pada DLBS1033 mirip dengan tissue plasminogen activator (t-PA), sehingga memungkinkan adanya aktivitas trombolitik terhadap fibrin.
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DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic…
The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity. F…
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