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Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract ri…
The present studywas conducted to evaluate in vitro and in vivo the antioxidant and anti-inflammatory properties of a cantaloupe melon (Cucumis melo LC., Cucurbitaceae) extract (CME) selected for its high superoxide dismutase activity. Peritoneal macrophages were pre-activated in vitro with 300 IU of interferon- (IFN-) and were then challenged in culture with IgGl/anti-IgG1 immune complexes (…
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Ondansetron: recommended antiemetics for patients with acute pancreatitis? a …
Ondansetron administration is a common antemetic of acute pancreatitis therapy in the intensive care unit (ICU), but its actual association with patients’ outcomes has not been confirmed. The study is aimed to determine whether the multiple outcomes of ICU patients with acute pancreatitis could benefit from ondansetron.
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Effect of ondansetron on nausea and vomiting after middle ear surgery during …
The efficacy of ondansetron 4 mg and 8 mg was compared with placebo in the reduction of postoperative nausea, retching and vomiting (PONV) after middle ear surgery during general anaesthesia, in 75 patients, in a double-blind and randomized study. Both doses of ondansetron were predictors for a decrease in PONV and the number of doses of rescue antiemetic needed per patient (droperidol: from 0.…
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Ondansetron-induced QT prolongation among various age groups: a systematic re…
d Ondansetron is a selective 5-hydroxytryptamine type 3 serotonin-receptor antagonist with antiemetic properties used inadvertently in the emergency department for controlling nausea. However, ondansetron is linked with a number of adverse efects, including prolongation of the QT interval. Therefore, the purpose of this meta-analysis was to assess the occurrence of QT prolongation in pediatri…
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Ondansetron oral disintegrating tablets for the prevention of postoperative v…
Strabismus surgery in pediatric patients is associated with a high incidence of postoperative nausea and vomiting (PONV). Ondansetron disintegrating tablets (ODT), an oral freeze-dried formulation of the 5-HT3 antagonist, are well-tolerated and have been shown to reduce chemotherapy-induced vomiting. The purpose of this study was to assess the effi cacy of the ODT in preventing postoperative v…
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Treatment of hyperemesis gravidarum with the 5-HT3 antagonist ondansetron (Zo…
Ondansetron is a 5-hydroxytryptamine receptor antagonist which is known to be a highly effective anti-emetic drug for chemotherapy-associated nausea and vomiting and for postoperative nausea. We report here a case where ondansetron was used in severe hyperemesis gravidarum to avoid parenteral nutrition. The drug was used intermittently in every trimester with no apparent adverse effects on mo…
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EFFECT OF CENTELLA ASIATICA ON MILD COGNITIVE IMPAIRMENT (MCI) AND OTHER COMM…
Centella asiatica is an herb used since ancient time in Ayurveda to improve mild cognitive functioning. The current study aimed to managing the cognitive functioning in elderly with mild cognitive impairment (MCI) and other age related problems. MCI is a serious problem which may be converted into Alzheimer disease. Although the concept of MCI is based on the presence of specific cognitive def…
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EFFECT OF CENTELLA ASIATICA LEAVES EXTRACT ON HIPPOCAMPAL CA3 NEURONS: A MORP…
Centella asiatica is a perennial herbaceous creeper, growing in moist soil. It has anti-thrombotic, antibacterial and antiinflammatory properties. In Ayurvedic medicine, Centella asiatica is used extensively as brain tonic to enhance the neural function, learning and memory. In the present study, the neuroprotective role of Centella asiatica (CeA) leaves extract on hippocampal CA3 neurons again…
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Alleviating Effect of Phyllanthus niruri on Sensorimotor and Cognitive Change…
Studies in animal models and humans have shown that chlorpyrifos (CPF) causes sensorimotor and cognitive changes. Apart from inhibiting acetylcholinesterase (AChE), the induction of oxidative stress is one of the other molecular mechanisms implicated in OP-evoked toxicity. The present study evaluated the alleviating effect of Phyllanthus niruri, a flavonoid rich plant, on subacute CPF-evoked se…
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Safety of Favipiravir for Treatment of COVID-19: Latest Systematic Review
Adverse event studies of favipiravir used to treat COVID-19 have been ongoing since it was established as a treatment option. A better understanding of the side effects of favipiravir from recent studies is important for developing and assessing the introduction of effective treatments for COVID-19
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