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Time for OBGYNs to Care for People of All Genders
There are at least 1.5 million transgendera individuals (0.5% by a household population based survey) in the United States.1 Although transgender individuals are often closeted, marginalized, and maligned there is growing social, political, and medical awareness. In June 2014, actress Laverne Cox became the first openly transgender person to be on the cover of Time Magazine
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OBGYN screening for environmental exposures: A call for action
Prenatal exposures have known adverse effects on maternal and neonatal outcomes. Professional societies recommend routine screening for environmental, occupational, and dietary exposures to reduce exposures and their associated sequelae.
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Heart failure drug treatment
Heart failure is the most common cardiovascular reason for hospital admission for people older than 60 years of age. Few areas in medicine have progressed as remarkably as heart failure treatment over the past three decades. However, progress has been consistent only for chronic heart failure with reduced ejection fraction. In acutely decompensated heart failure and heart failure with preser…
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Atrial fibrillation and stroke: a practical guide
Neurologists and stroke physicians will be familiar with atrial fibrillation as a major cause of ischaemic stroke, and the role of anticoagulation in preventing cardioembolic stroke. However, making decisions about anticoagulation for individual patients remains a difficult area of clinical practice, balancing the serious risk of ischaemic stroke against that of major bleeding, particularly in…
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Alopecia Areata and Down Syndrome: A True Association or a Coincidence
The cause of alopecia areata (AA) is not entirely understood, although a strong genetic basis for this condition has been suggested.[1] Several studies have showed that AA is associated with Down syndrome (DS), implicating that a causative gene for this condition is located on chromosome 21
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P-glycoprotein and its role in drug-drug interactions
Important substrates of P-glycoprotein include calcium channel blockers, cyclosporin, dabigatran etexilate, digoxin, erythromycin, loperamide, protease inhibitors and tacrolimus. Predicting clinically important interactions is difficult because of interindividual differences in drug transport
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Overview of P-glycoprotein inhibitors: a rational outlook
P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP binding cassette (ABC) super family that functions specifically as a carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resista…
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Potential Benefits of pH 8.8 Alkaline Drinking Water as an Adjunct in the Tre…
Unlike conventional drinking water, pH 8.8 alkaline water instantly denatures pepsin, rendering it permanently inactive. In addition, it has good acid-buffering capacity. Thus, the consumption of alkaline water may have therapeutic benefits for patients with reflux disease
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A Comparison of AlkalineWater and Mediterranean Diet vs Proton Pump Inhibitio…
Laryngopharyngeal reflux (LPR) is a common disorder with protean manifestations in the head and neck. In this retrospective study, we report the efficacy of a wholly dietary approach using alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions compared with that of the traditional treatment approach of proton pump inhibition (PPI) and standard reflux precaut…
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Evaluation of the GeneXpert MTB/RIF Assay for Rapid Diagnosis of Tuberculosis…
Mycobacterium tuberculosis remains one of the most significant causes of death from an infectious agent. The rapid diagnosis of tuberculosis and detection of rifampin (RIF) resistance are essential for early disease management. The GeneXpert MTB/RIF assay is a novel integrated diagnostic device for the diagnosis of tuberculosis and rapid detection of RIF resistance in clinical specimens.
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