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Anaemia in kidney disease: harnessing hypoxia responses for therapy
Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided new insights into the pathogenesis of anaemia associated with renal failure and has led to the development of novel therapeutic agents for its treatment. Hypoxia-inducible factor (HIF)‑2 is a key regulator of erythropoiesis and iron metabolism. HIF‑2 is activated by hypoxic conditions and controls the p…
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Pathophysiology of renal anaemia
Anaemia remains a prominent feature of chronic kidney disease (CKD). The prevalence is inversely correlated with kidney function, and the vast majority of patients with CKD Stage 5 develop anaemia [
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Uji Klinik Buta Ganda Perbedaan Profil Perdarahan Dan Outcome Klinis Pasien S…
DLBS1033 adalah enzim protease fibrinolitik yang bekerja menghidrolisis fibrin atau fibrinogen dan menstimulasi plasminogen menjadi plasmin. Plasminogen activator (e-PA) pada DLBS1033 mirip dengan tissue plasminogen activator (t-PA), sehingga memungkinkan adanya aktivitas trombolitik terhadap fibrin.
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DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic…
The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity. F…
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Guidelines on the diagnosis and management of acute pulmonary embolism
Guidelines and Expert Consensus Documents summarize and evaluate all currently available evidence on a particular issue with the aim of assisting physicians in selecting the best management strategies for a typical patient, suffering from a given condition, taking into account the impact on outcome, as well as the risk/benefit ratio of particular diagnostic or therapeutic means. Guidelines ar…
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Multidisciplinary OBGYN morbidity and mortality conference
Obstetrics and gynecology (OB-GYN) morbidity and mortality conferences allow for review of cases with poor or avoidable outcomes. Little data exist on standardized formats for presentation and evaluation. We designed a multidisciplinary morbidity and mortality conference. We formally evaluated resident performance using the milestones format, and evaluated resident understanding of case concep…
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Prediction of postpartum hemorrhage in women with gestational hypertension or…
To assess whether postpartum hemorrhage can be predicted in women with gestational hypertension or mild preeclampsia at term. Design. A cohort study in which we used data from our multicentre randomized controlled trial (HYPITAT trial). Setting. The study was conducted in 38 hospitals in the Netherlands between 2005 and 2008.
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Assessment of quality of care among in-patients with postpartum haemorrhage a…
The maternal mortality ratio of Uganda is still high and the leading causes of maternal mortality are postpartum haemorrhage (PPH), severe pre-eclampsia and eclampsia. Criteria-based audit (CBA) is a way of improving quality of care that has not been commonly used in low income countries. This study aimed at finding out the quality of care provided to patients with these conditions and to find …
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Mechanisms of action of intrauterine devices: Update and estimation of postfe…
There are many potential mechanisms of action for the intrauterine device (IUD), which vary by type of IUD (inert, copper, or hormonal). This paper reviews the evidence for each potential mechanism of action. On the basis of available data for fertilization rates and clinical pregnancy rates, the relative contribution of mechanisms acting before or after fertilization were quantitatively estima…
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Intrauterine Devices: An Update
Three intrauterine devices (IUDs) are available in the United States: the copper T 380A and two levonorgestrel-releasing IUDs, one that releases 20 mcg of levonorgestrel per 24 hours, and one that releases 14 mcg per 24 hours. All are safe and effective methods of contraception that work predominantly by prefertilization mechanisms. The copper T 380A IUD may be placed in nonpregnant women at an…
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