Practical management of peripartum cardiomyopathy

Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that causes systolic heart failure (HF) in previously healthy young women. Despite latest remarkable achievement, unifying pathophysiologic mechanism is not well established. Considering close temporal relationship to pregnancy, the recent prolactin theory is promising.

Trends in long-term prognosis after acute coronary syndrome

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Non–ST-Segment Acute Coronary Syndromes

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An update on PCOS in adolescents

Polycystic ovarian syndrome (PCOS) is a common endocrinopathy which can be difficult to treat in adolescents. Fortunately, early identification and treatment can help mitigate some of the metabolic complications. In this review, we reflect on recent literature regarding PCOS diagnosis, associated complications, and treatment options.

Tissue Characterization with Gray-level Histogram Width in Obstetrics and Gyn…

Malignant GLHW was higher than in benign one (it was malignant if the GLHW was 50% or more in ovary, uterine cervix, and endometrium). The GLHW of placental fibrin deposit was higher than normal placenta. It was reduced by heparin and normal neonate was obtained. Fetal brain echo density, immature fetal lung, and meconium-stained amniotic fluid were diagnosed by GLHW, and normal adult liver …

G-CSF and GM-CSF in Neutropenia

Granulocyte Colony Stimulating Factor (G-CSF) and Granulocyte/Macrophage Colony Stimulating Factor (GM-CSF) are used widely to promote the production of granulocytes or antigen presenting cells (APC). The Food and Drug Administration approved G-CSF (filgrastim) for the treatment of congenital and acquired neutropenias and for mobilization of peripheral hematopoietic progenitor cells for stem ce…

Efficacy and Safety of Entecavir Versus Adefovir in Chronic Hepatitis B Patie…

A randomized, open-label comparative study of entecavir versus adefovir therapy was performed in subjects with chronic hepatitis B who had hepatic decompensation (Child-Turcotte-Pugh score
7). Adult subjects were randomized and treated (n 5 191) with entecavir 1.0 mg or adefovir 10 mg daily for up to 96 weeks from the date of last subject randomization. Subjects were positive or negative for …

Four-Year Entecavir Therapy Reduces Hepatocellular Carcinoma, Cirrhotic Event…

Oral antiviral therapy may reduce the disease progression of chronic hepatitis B (CHB) patients. We aimed to further investigate the efficacy of long-term entecavir therapy in reduction the risk of hepatocellular carcinoma (HCC), cirrhotic events and mortality in a large group of CHB-related cirrhosis patients

Entecavir maleate versus entecavir in Chinese chronic hepatitis B predominant…

Reports on the efficacy and safety of long-term entecavir treatment in chronic hepatitis B (CHB) predominantly genotype B or C are insufficient. This study presents the efficacy and safety of entecavir maleate in Chinese CHB patients. Patients were randomly assigned to receive 48-week treatment with either 0.5mg/day entecavir (group A) or 0.5mg/day entecavir maleate (group B), then all patients…

Role of Yes-Associated Protein 1, Angiomotin and Mitogen Activated Kinase Kin…

The morula-stage embryo is transformed into a blastocyst composed of epiblast, hypoblast and trophectoderm (TE) through mechanisms that, at least in the mouse, involve the Hippo signaling and mitogen-activated kinase (MAPK) pathways. Using the cow as an additional model, we tested the hypotheses that TE and hypoblast differentiation were regulated by the Hippo pathway regulators, YAP1 and AMOT,…