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Pre-Eclampsia and Eclampsia: An Update on the Pharmacological Treatment Appli…
Pre-eclampsia and eclampsia are two hypertensive disorders of pregnancy, considered major causes of maternal and perinatal death worldwide. Pre-eclampsia is a multisystemic disease characterized by the development of hypertension after 20 weeks of gestation, with the presence of proteinuria or, in its absence, of signs or symptoms indicative of target organ injury. Eclampsia represents the con…
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Preeclampsia and cardiovascular disease: interconnected paths that enable det…
The potent and now longstanding evidence of the association between placentationrelated disorders and cardiovascular disease should be translated into clinical practice in order to introduce a preventive approach to future obstetric and cardiovascular diseases. The purpose of this review is to integrate cardiovascular risk/disease and obstetric complications, which are linked by endothelial dy…
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Toxoplasmosis in pregnancy
Pregnant women who acquire infection from Toxoplasma gondii usually remain asymptomatic, although they can still transmit the infection to their fetuses with severe consequences. Given the asymptomatic nature of most Toxoplasma infections, primary prevention in pregnant women may lower the risk of congenital toxoplasmosis. Both consumption of undercooked meat and unprotected contact with soil a…
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Toxoplasmosis in Pregnancy: Prevention, Screening, and Treatment
One of the major consequences of pregnant women becoming infected by Toxoplasma gondii is vertical transmission to the fetus. Although rare, congenital toxoplasmosis can cause severe neurological or ocular disease (leading to blindness), as well as cardiac and cerebral anomalies. Prenatal care must include education about prevention of toxoplasmosis. The low prevalence of the disease in the Can…
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Long-term Effects of Metformin on Diabetes Prevention: Identification of Subg…
We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS).
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Angiotensin converting enzyme and angiotensin II type 1-receptor gene polymor…
Polymorphisms in several genes of the renin–angiotensin system have been implicated as risk factors for myocardial infarction and ischaemic heart disease. In particular, it has been suggested that the angiotensin converting enzyme insertion / deletion 1166 (I /D) polymorphism and the angiotensin II type 1 receptor A C polymorphisms might act synergistically to increase the risk of myocardi…
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Acute Hepatitis
Acute hepatitis is a nonspecific term that refers to an acute inflammation of the liver resulting from a wide range of etiologies. Even though the presentation may be acute, it does not always result from an acute disease process. Many of the etiologies may have a long-standing silent disease process preceding the acute presentation. The clinical presentation can be overlapping and therefore…
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Acute infectious hepatitis in hospitalised children: a British Paediatric Sur…
Hepatitis remains a key public health priority globally. Most childhood cases are caused by viruses, especially hepatitis A virus (HAV) and hepatitis B virus (HBV). This study aimed to estimate the burden of acute infectious hepatitis in hospitalised children and to describe their clinical characteristics and outcomes
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Acute hepatitis A is the chief etiology of acute hepatitis in Egyptian childr…
Acute hepatic illness is an important health issue in children. Our work aimed to determine the prevalence of viral hepatitis in symptomatic children. It is a prospective cohort study of 268 children presented with acute hepatitis. Complete blood count, liver panel, and anti-hepatitis Avirus (HAV) IgM were done initially. Cases negative for HAV were tested for anti-hepatitis E (HEV) IgM, ant…
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Use of Diphtheria Antitoxin (DAT) for Suspected Diphtheria Cases IND
The purpose of this Investigational New Drug (IND) protocol is to provide access to diphtheria antitoxin (DAT) for emergency treatment of suspected diphtheria cases and, under exceptional circumstances, to provide passive, transient protection against diphtheria toxin in an exposed contact. A FDA-licensed diphtheria antitoxin product is unavailable in the United States.
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