Metformin: New Preparations and Nonglycemic Benefits

Metformin has been widely used for over 5 decades. New preparations have been developed for possible enhancement of efficiency, tolerability, and pleiotropic nonglycemic effects. Extended-release metformin has contributed to adherence and improved gastrointestinal tolerability. Delayed-release metformin acts in the lower gastrointestinal tract and exerts glucose-lowering effects at lower plasma…

Metformin and metabolic diseases: a focus on hepatic aspects

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibit…

Targeted Therapy as an Alternative to Whole-Brain Radiotherapy in EGFR-Mutant…

Patients with advanced EGFR-mutant or ALK-positive non–smallcell lung cancer (NSCLC) have a high cumulative risk (>70%) for developing brainmetastases (BrM) during the course of their disease. Recently, an update of the graded prognostic assessment (GPA) for patients with NSCLCandBrMhas established that molecular alterations in EGFR or ALK are an independent prognostic factor for betteroutcomes.

Role of chemotherapy and targeted therapy in early-stage non-small cell lung …

Adjuvant platinum based chemotherapy is accepted as standard of care in stage II and III non-small cell lung cancer (NSCLC) patients and is often considered in patients with stage IB disease who have tumors ≥ 4 cm. The survival advantage is modest with approximately 5% at 5 years

Updated Neonatal Resuscitation Guidelines 2015 – Major Changes

The latest guidelines on neonatal resuscitation from American Heart Association (AHA) [1] and European Resuscitation Council (ERC) [2] were released in October 2015. There have been slight variations between these guidelines; although they use nearly identical literature for evidence evaluation. We present here the major changes in the recent guidelines [3,4], and comparison between the ERC a…

Neonatal Resuscitation

Neonatal cardiac arrest is predominantly asphyxial, so initiation of ventilation remains the focus of initial resuscitation

NEONATAL RESUSCITATION PROGRAM 7th EDITION UPDATES

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

-

Oesophageal foreign body in the left main bronchus

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

-

Foreign body in the bronchus in children: 22 years experience in a tertiary c…

Our objective was to assess types, presentation, duration of symptoms and usefulness of rigid bronchoscopy for diagnosis and treatment of bronchial foreign body (FB) in children

THE CONCEPTUAL AND CLINICAL PROBLEMS OF PARANEOPLASTIC SYNDROME IN ONCOLOGY A…

Symptomatology of oncological diseases consists not only of local symptoms caused by the primary malignancy or its metastases, but also by general systemic signs that are not directly connected with the tumor. These symptoms are mostly associated with autoimmunity or endocrine influences. In many cases, the source of paraneoplastic syndromes (PNS) is unknown. Nearly 15% of oncological patients …