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The Role of Hippo/YAP Signaling in Vascular Remodeling and Related Diseases
Vascular remodeling is a vital process of a wide range of cardiovascular diseases and represents the altered structure and arrangement of blood vessels. The Hippo pathway controls organ size by regulating cell survival, proliferation and apoptosis. Yes-associated protein (YAP), a transcription coactivator, is a downstream effector of the Hippo pathway. Emerging evidence supports that the Hippo/…
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Tsunami Lung in Great East Japan Earthquake 2011: Clinical Time Course, Featu…
Drowning was the cause of death in almost all victims of the Great East Japan Earthquake Tsunami (GEJET). People who experienced near-drowning suffered from Tsunami lung afterward. Tsunami lung is initiated by the aspiration of a vast amount of sea water including sand, sludge from the sea bottom, small pieces of wood, petroleum, and undefined chemicals. Physical and chemical insults on the pu…
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Massive Hemoptysis
Hemoptysis, or coughing of blood, oftentimes triggers anxiety and fear for patients. The etiology of hemoptysis will determine the clinical course, which includes watchful waiting or intensive care admission. Any amount of hemoptysis that compromises the patient’s respiratory status is considered massive hemoptysis and should be considered a medical emergency. In this article, we review intro…
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Extreme recurrent massive hemoptysis in a cystic fibrosis patient requiring 2…
While bronchial artery embolization is an established, safe, and effective treatment for massive hemoptysis from a variety of causes including cystic fibrosis, patients rarely require more than 2 angiography and embolization treatments during their lifetime. We present a rare case of massive, recurrent hemoptysis requiring a total of 22 angiography and embolization procedures over a period of 8…
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Recent advances in pediatric oncology
Newadvances in the field of pediatric oncology have had a tremendous impact on our approach to the diagnosis and treatment of childhood cancer over the past decade. This exciting era of discovery holds great promise for the successful treatment of an increasing number of heretofore incurable childhood cancers. Targeting molecular aberrations in tumors and/or modulating the immune system to max…
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Massive hemoptysis due to recurrence of bronchial to pulmonary vascular malfo…
Bronchial dieulafoy lesions are quite rare with relatively few case reports in the literature. Symptoms may vary but the lesion is often associated with hemoptysis and may present as massive hemoptysis. We present a case of a 69-year-old male with a recurrent episode of hemoptysis three years after treatment for a bronchial dieulafoy lesion. The bronchoscopy done three years prior during an ini…
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Evaluation of New Technologies in Gastrointestinal Endoscopy
Gastrointestinal (GI) tumors are the most commonly diagnosed cancers worldwide and the second leading cause of cancer-related death. Endoscopy is the gold standard for diagnosis of GI cancers. Early diagnosis of GI tumors by endoscopy at the precancerous or early stage may decrease the prevalence and mortality rate of GI cancers. The preventive role of endoscopic interventions and the limitatio…
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Serum Levels of FGF21 and Prediction of Cardiovascular Events
Over the last decade, the discovery of endocrine fibroblast growth factors (eFGFs) and their signaling pathways with regulatory functions in cell metabolism, but not proliferation, is among the major breakthroughs in the field of endocrinology and metabolism [1, 2]. Among eFGFs, FGF21 has attracted much attention as a potential pharmacotherapy against major metabolic diseases, such as obesity, …
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Risk of Hospitalization for Cardiovascular Events with b-Blockers in Hyperten…
Incident nebivolol, atenolol, or metoprolol monotherapy users with hypertension were identified using US claims data (2007–2014). The first b-blocker claim on/after 1/1/2008 defined the index drug/date. Hypertensive patients without pre-index cardiovascular history were followed until index drug discontinuation ([90 day supply gap), use of other b-blockers, or end of continuous plan enrollment
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Cardiovascular Complications of Marijuana and Related Substances: A Review
The recreational use of cannabis has sharply increased in recent years in parallel with its legalization and decriminalization in several countries. Commonly, the traditional cannabis has been replaced by potent synthetic cannabinoids and cannabimimetics in various forms. Despite overwhelming public perception of the safety of these substances, an increasing number of serious cardiovascular adv…
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