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Pre-Eclampsia Increases the Risk of Postpartum Haemorrhage A Nationwide Cohor…
Postpartum haemorrhage is a leading cause of maternal morbidity and mortality worldwide. Identifying risk indicators for postpartum haemorrhage is crucial to predict this life threatening condition. Another major contributor to maternal morbidity and mortality is pre-eclampsia. Previous studies show conflicting results in the association between preeclampsia and postpartum haemorrhage. The p…
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Toxoplasmosis and pregnancy
Low prevalence of the infection, high cost associated with testing, low sensitivity of screening tests, falsepositive test results, and limitations of treatment effectiveness are all cited as reasons for not routinely screening for T gondii infection in Canada. Currently, screening for the detection of T gondii is only performed in Nunavik and other parts of northern Quebec owing to the high…
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Tailoring Natural Killer cell immunotherapy to the tumour microenvironment
Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity. Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we review the various cellular and molecular pathways that tumours have…
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Measurement of uterine natural killer cell percentage in the periimplantation…
Uterine natural killer cells are the major leukocytes present in the periimplantation endometrium. Previous studies have found controversial differences in uterine natural killer cell percentage in women with recurrent reproductive failure compared with fertile controls.
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The Role of Angiotensin-Converting Enzyme Polymorphism in Congestive Heart Fa…
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase, with primary known functions of converting angiotensin I into the vasoactive and aldosterone-stimulating peptide angiotensin II and inactivating bradykinin. There is high variability among individuals in ACE concentrations, mainly due to the presence of a genetic polymorphism. The ACE gene has, in fact, insertion/ deletion polym…
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An Analysis of Risk Factors for Incomplete Immunization for Children in Côte…
Immunization is said to be the most effective public health intervention to prevent morbidity, complications, and mortality due to infectious disease among children. Due to the importance of vaccination in terms of infectious disease prevention, in terms of high cost-effectiveness ratio, international organizations, governments, and donors have intensified efforts to increase immunization cove…
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Diabetes Self-management Education and Support in Type 2 Diabetes - A Joint P…
Diabetes is a chronic disease that requires a person with diabetes to make a multitude of daily self-management decisions and perform complex care activities. Diabetes self-management education and support (DSME/S) provides the foundation to help people with diabetes to navigate these decisions and activities and has been shown to improve health outcomes
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A 9-year-old boy with severe diphtherial infection and cardiac complications
The incidence of diphtheria has decreased since the introduction of an effective vaccine. However, in countries with low vaccination rates it has now become a reemerging disease. Complications from diphtheria commonly include upper airway obstruction and cardiac complications. We present a 9-year-old boy who was diagnosed with diphtheria. He presented with fever, tonsilar plaques, respiratory f…
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The Pathology of Diphtheria
Diphtheria is an acute, communicable disease caused by Corynebacterium diphtheriae. The disease is generally characterized by local growth of the bacterium in the pharynx with pseudomembrane formation or, less commonly, in the stomach or lungs; systemic dissemination of toxin then invokes lesions in distant organs. Acute disease of the upper respiratory tract usually involves one or more of th…
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Fatal diphtheria myocarditis in a 3-year-old girl—related to late availabil…
Sporadic cases of diphtheria are very rare throughout Europe. A 3-year-old incompletely vaccinated girl was admitted with pharyngotonsillitis caused by diphtheria. On day 9 of her illness, renal and cardiac failure with a third-degree AV-block occurred. Unfortunately, she died within 36 h of admission to intensive care, despite pacemaker placement, the administration of antibiotics and diph…
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