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The evolution of coronary stents
Percutaneous coronary intervention (PCI) is 40 years old this year. From its humble beginnings of experimental work, PCI has transitioned over years with coronary artery stenting now a standard medical procedure performed throughout the world
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Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia
To analyze the course of maternal diseases and compare pregnancy outcomes in patients with systemic lupus erythematosus (SLE)-associated thrombocytopenia to patients without
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Acute Limb Ischemia
A 57-year-old man presents with an acute onset of left foot pain, numbness, and partial loss of motor function. Four months ago, he underwent endovascular treatment for disabling claudication, which included placement of overlapping polytetrafluoroethylene- coated stents in the left superficial femoral and popliteal arteries. His popliteal and pedal pulses are absent, and the foot is cool and …
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Stress echocardiography combined with cardiopulmonary exercise testing: Openi…
According to consensus recommendations, a diagnosis of heart failure with preserved ejection fraction (HFpEF) can be obtained when three requirements are met simultaneously: signs and symptoms of heart failure; preserved left ventricular (LV) global systolic performance (ejection fraction by echocardiography >50% and LV end-systolic volume
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The combined exercise stress echocardiography and cardiopulmonary exercise te…
Heart failure with preserved ejection fraction (HFpEF) is commonly associated with hypertension (HTN). However, resting echocardiography (ECHO) can underestimate the severity of disease. Exercise stress echocardiography (ESE) and the cardiopulmonary exercise testing (CPX) appeared to be useful tests in dynamic assessment of HFpEF. The value of combined exercise stress echocardiography cardio…
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Cerebral Intraparenchymal Hemorrhage : A Review
Although spontaneous intraparenchymal hemorrhage (IPH) accounts for less than 20%of cases of stroke, it continues to be associated with the highest mortality of all forms of stroke and substantial morbidity rates
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Safety of ambroxol in the treatment of airway diseases in adult patients
Ambroxol is a widely used secretolytic and mucoactive over-the-counter agent primarily used to treat respiratory diseases associated with viscid mucus. Following post-marketing reports of hypersensitivity reactions and severe cutaneous adverse reactions (SCARs) possibly linked to ambroxol, the European Union’s Pharmacovigilance Risk Assessment Committee (PRAC) initiated in April 2014 a review…
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Informed Consent in Pediatric Research
Pediatric drug research is gradually becoming more and more accepted as the norm for assessing whether a drug is safe and efficacious for infants and children. The process of informed consent and assent for these trials presents a major challenge. The aim of this review is to map historical, ethical and legal aspects relevant to the challenges of informed consent in the setting of pediatric dru…
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Metabolic Control in Type 1 Diabetes: Is Adjunctive Therapy the Way Forward?
Despite advances in insulin therapies, patients with type 1 diabetes (T1DM) have a shorter life span due to hyperglycaemia-induced vascular disease and hypoglycaemic complications secondary to insulin therapy. Restricting therapy for T1DM to insulin replacement is perhaps an over-simplistic approach, and we focus in this work on reviewing the role of adjuvant therapy in this population.
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Strategies for Diabetes Management: Using Newer Oral Combination Therapies Ea…
The duration of uncontrolled type 2 diabetes mellitus (T2DM) can adversely impact small and large vessels, eventually leading to microvascular and macrovascular complications. Failure of therapeutic lifestyle changes, monotherapy, and clinical inertia contribute to persistent hyperglycemia and disease progression.
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