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CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic …
To assess the role of alveolar macrophages (AMs) during a pulmonary Aspergillus fumigatus infection AMs were depleted by intratracheal application of diphtheria toxin (DTX) to transgenic CD11c.DTR mice prior to fungal infection. Unexpectedly, all CD11c.DTR mice treated with DTX died within 4–5 days, whether being infected with A. fumigatus or not. Despite measurable impact of DTX on lung func…
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Massive Hemoptysis with a Fungus Ball-like Shadow in an Old Tuberculosis Cavi…
Development of aspergilloma is common in cases with a fungus ball-like shadow in cavities due to old tuberculosis. Some reports have shown that blood clots tend to appear as a fungus ball-like shadow. A 71-yearold man with a history of pulmonary tuberculosis presented with a fungus ball-like shadow in an old cavity and hemoptysis. There was no evidence of aspergillus infection on various exa…
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ACE (I/D) polymorphism and response to treatment in coronary artery disease: …
In view of available evidence, genetic testing of ACE I/D polymorphism prior to clinical decision making is not currently justified. The relation between ACE genetic variation and response to treatment in CAD remains an unresolved issue. The results of long-term and properly designed prospective studies hold the promise for pharmacogenetically tailored therapy in CAD.
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AADE Guidelines for the Practice of Diabetes Self-Management Education and Tr…
The American Association of Diabetes Educators (AADE) is a multidisciplinary professional association dedicated to providing diabetes educators with the tools, training, and support necessary to help patients change their behavior and accomplish their diabetes self-management goals. The AADE is constantly working toward its vision of successful self-management for all people with diabetes and …
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Leveraging natural killer cells for cancer immunotherapy
Natural killer (NK) cells are potent antitumor effector cells of the innate immune system. Based on their ability to eradicate tumors in vitro and in animal models, significant enthusiasm surrounds the prospect of leveraging human NK cells as vehicles for cancer immunotherapy. While interest in manipulating the effector functions of NK cells has existed for over 30 years, there is renewed opti…
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Renal handling of zinc in chronic kidney disease patients and the role of cir…
Zinc levels are lower in CKD, and not compensated by reduced renal zinc excretion. The inverse association between urinary zinc excretion and uromodulin possibly points to an impaired tubular activity, which could partly account for zinc imbalance in CKD. These data suggest that zinc status is associated with renal function decline, but further studies elucidating the underlyingmechanisms and …
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Randomized prospective comparison between erythropoietin and androgens in CAP…
Anemia and malnutrition are significant com- served with rHuEPO. Furthermore, compared with rHuEPO, complications in peritoneal dialysis (PD) patients. Previous studies androgen administration was associated with beneficial effects in hemodialysis have shown that androgens are effective as on nutritional status. The mechanism of action of androgens therapy for anemia; however, this has not be…
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International trends in erythropoietin use and hemoglobin levels in hemodialy…
Hemoglobin levels and the dose of erythropoiesisstimulating agents (ESAs) have risen over time in hemodialysis patients within the United States. There are concerns that these trends may be driven by reimbursement policies that provide potential incentives to increase this use. To determine this we studied trends in the use of ESA and hemoglobin levels in hemodialysis patients and the relations…
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Hemoglobin, erythropoietin and systemic inflammation in exacerbations of chro…
In this observational study we have shown that during admission for ECOPD Hb levels are decreased and EPO levels are increased. We have also identified a negative association between Hb and EPO. The above association is mainly related to increased IL-6 levels, indicating a possible EPO resistance through the mechanism of increased systemic inflammatory process.
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Hemoglobin Levels and Erythropoietin Doses in Hemodialysis and Peritoneal Dia…
Erythropoietic agents, a cornerstone of management, are a major component of the cost of renal replacement therapy. The objectives of this study were to compare (on a month-by-month basis) U.S. hemodialysis and peritoneal dialysis patients in terms of the proportion of patients receiving erythropoietin, erythropoietin doses, and hemoglobin levels after initiation of erythropoietin.
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