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Implicit and Explicit Memory Following Surgical Anesthesia
Paired associates were presented to 25 surgical patients following the induction of anesthesia by thiopental, vecuronium, and isoflurane. Postoperative testing (immediately or after two weeks) showed no free recall for the list; nor was there significant cued recall or recognition, compared to ,a matched control list.
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A global vision for the British Journal of Anaesthesia
Welcome tomy first issue as the 12th Editor-in-Chief of the British Journal of Anaesthesia. Although many may be surprised by the selection of an American to lead a historically British journal, this development reflects the evolution of the BJA as the premiere international journal in anaesthesia. As Professor Jennie Hunter noted in her review of the early history of the BJA, I am not even its…
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Volume 100: basic sciences in the British Journal of Anaesthesia
Basic sciences in anaesthesia, and more specifically basic science papers published in the British Journal of Anaesthesia (BJA), provoke widely differing responses. To begin by being provocative, and honest, we have all heard our colleagues (and maybe yourself ) question the place of this type of material in the official journal of your medical Royal College
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Is There Any Correlation Between Lactate And Base Excess In Septic Shock Pati…
Clinical, hemodynamics and perfusion variable are important tools in identify instable patients and guide therapy. Increased arterial lactate and decreased base excess (BE) have been shown to be predictive of depth of shock and severity of injury
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Lung cancer: current therapies and new targeted treatments
Lung cancer is the most frequent cause of cancer-related deaths worldwide. Every year, 1·8 million people are diagnosed with lung cancer, and 1·6 million people die as a result of the disease. 5-year survival rates vary from 4–17% depending on stage and regional diff erences. In this Seminar, we discuss existing treatment for patients with lung cancer and the promise of precision medicin…
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Lung Cancer Screening: Advantages, Controversies, and Applications
Lung cancer is the leading cause of cancer death in the United States. Results from the National Lung Screening Trial (NLST) have shown that low-dose computed tomography (CT) is capable of detecting lung neoplasms in individuals at high risk. However, whether it is advantageous to perform lung cancer screening on these patients is a significant concern, as are the potential adverse outcomes …
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Clinical effectiveness of cell therapies in patients with chronic liver disea…
Chronic liver disease (CLD) is a major health burden worldwide. Liver cirrhosis, a form of CLD is the fifth most common cause of death in the UK. Acute-on-chronic liver failure (ACLF) is the result of an acute insult superimposed on patients with liver cirrhosis as a result of precipitating events such as infection or bleeding. ACLF has a high associated mortality as a result of multi-organ …
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Nitric oxide synthase regulation of cardiac excitation–contraction coupling…
Significant advances in our understanding of the ability of nitric oxide synthases (NOS) tomodulate cardiac function have provided key insights into the role NOS play in the regulation of excitation–contraction (EC) coupling in health and disease. Through both cGMP-dependent and cGMP-independent (e.g. S-nitrosylation) mechanisms, NOS have the ability to alter intracellular Ca2+ handling an…
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Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell…
Results of small-scale studies have suggested that stem-cell therapy is safe and effective in patients with liver cirrhosis, but no adequately powered randomised controlled trials have been done. We assessed the safety and efficacy of granulocyte colony-stimulating factor (G-CSF) and haemopoietic stem-cell infusions in patients with liver cirrhosis.
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Role of Platelet, Blood Stem Cell, and Thrombopoietin in Liver Regeneration, …
Platelets are anuclear blood cells derived from thrombopoietin (TPO)-stimulated megakaryocytes; they not only play a critical role in hemostatsis, but also secrete several growth factors, including platelet-derived growth factor (PDGF) and hepatocyte growth factor (HGF) which are required for tissue regeneration or repair
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