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Open forensic science
The mainstream sciences are experiencing a revolution of methodology. This revolution was inspired, in part, by the realization that a surprising number of findings in the bioscientific literature could not be replicated or reproduced by independent laboratories. In response, scientific norms and practices are rapidly moving towards openness. These reforms promise many enhancements to the scien…
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Cultivating Research Skills During Clinical Training to Promote Pediatric-Sci…
Physician-scientists represent a critical component of the biomedical and health abstract research workforce. However, the proportion of physicians who spend a significant amount of effort on scientific research has declined over the past 40 years. This trend has been particularly noticeable in pediatrics despite recent scientific work revealing that early life influences, exposures, and health…
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Downward trend in pediatric resident laryngoscopy participation in pediatric …
As of July 2013, pediatric resident trainee guidelines in the United States (US) no longer require proficiency in non-neonatal tracheal intubation (TI). We hypothesized that laryngoscopy by pediatric residents has decreased over time, with a more pronounced decrease after this guideline change.
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Methodological and Ethical Issues in Pediatric Medication Safety Research
In May 2016, the Eshelman School of Pharmacy at The University of North Carolina at Chapel Hill convened the PharmSci conference to address the topic of “methodological and ethical issues in pediatric medication safety research.” A multidisciplinary group of experts representing a diverse array of perspectives, including those of the US Food and Drug Administration, children’s hospitals, …
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Current State of the First COVID-19 Vaccines
SARS CoV-2 and its associated disease COVID-19 has devastated the world during 2020. Masks and social distancing could be efficient if done by large proportions of the population, but pandemic fatigue has decreased their efficacy. Economic shut downs come with large price tags and cannot be a long term solution either. The announcements by three vaccine manufacturers in November that their vacc…
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Respiratory follow-up of patients with COVID-19 pneumonia
The COVID-19 pandemic has led to an unprecedented surge in hospitalised patients with viral pneumonia. The most severely affected patients are older men, individuals of black and Asian minority ethnicity and those with comorbidities. COVID-19 is also associated with an increased risk of hypercoagulability and venous thromboembolism.
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Severe COVID-19 Lung Infection in Older People and Periodontitis
Periodontal bacteria dissemination into the lower respiratory tract may create favorable conditions for severe COVID-19 lung infection. Once lung tissues are colonized, cells that survive persistent bacterial infection can undergo permanent damage and accelerated cellular senescence. Consequently, several morphological and functional features of senescent lung cells facilitate SARSCoV-2 replica…
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A Proactive Approach for Managing Covid-19: The Importance of understanding t…
Vaccination hesitancy—the reluctance or refusal to be vaccinated—is a leading global health threat (World Health Organization, 2019). It is imperative to identify the prevalence of vaccination hesitancy for SARS-CoV2 in order to understand the scope of the problem and to identify its motivational roots in order to proactively prepare to address the problem when a vaccine eventually becomes …
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Exploring the acceptability of controlled human infection with SARSCoV2—a p…
Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. This raises complex questions about the soc…
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The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded RNA virus with epithelial cell and respiratory system proclivity. Like its predecessor, SARS-CoV, COVID-19 can lead to life-threatening disease. Due to wide geographic impact affecting an extremely high proportion of the…
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