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Should formula for infants provide arachidonic acid along with DHA? A positio…
Recently adopted regulatory standards on infant and follow-on formula for the European Union stipulate that from February 2020 onwards, all such products marketed in the European Union must contain 20–50 mg omega-3 DHA (22:6n–3) per 100 kcal, which is equivalent to about 0.5–1% of fatty acids (FAs) and thus higher than typically found in human milk and current infant formula products, …
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The pain of weight gain: self-experimentation with overfeeding
The Vermont overfeeding studies were published 50 y ago and began a change in the acceptance of obesity as a bona fide area of academic interest. This article chronicles the experience of the author with acute weight gain while overfeeding, in the context of current obesity research, and presents a glimpse of things to come. The pain associated with acute overeating is illustrated by the first…
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Effect of dietary protein intake on albumin homeostasis in nephrotic patients
Animals with experimental renal disease maintained on dietsrest ricted in protein develop less severe renal lesions and less proteinuria than do animals maintained on a normal or high protein diet. To determine whether restriction of dietary protein will reduce urinary albumin excretion in patients with established nephroses and whether such dietary restriction will result in decreased albumi…
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A Meta-Analysis of the Effects of Dietary Protein Restriction on the Rate of …
Dietary protein restriction has been reported to delay the need for renal replacement therapy in clinical trials and meta-analyses. However, less clear is what effect dietary protein has on the rate of decline in renal function. We pooled the results of 13 randomized controlled trials (n 5 1,919 patients) and found that dietary protein restriction reduced the rate of decline in estimated glo…
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Nutritional Management of Nephrotic Syndrome
Nephrotic syndrome is caused by urinary loss of proteins of intermediate size. Albumin protein is lost in the greatest quantity, but important protein-bound nutrients-such as iron bound to transferrin, vitamin D bound to vitamin D-binding protein, copper bound to ceruloplasmin, and zinc bound mostly to albumin-are lost as well. The syndrome is characterized by hypoalbuminemia, edema formation, …
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Developing Strategies for Predicting and Preventing Readmissions in Vascular …
The escalating cost burden of hospital readmission has prompted recent nationwide efforts aimed at reducing the incidence of this important quality measure. Because patients undergoing vascular surgery account for a significant proportion of readmissions, vascular surgeons may face reduced reimbursements in the near future if these trends continue. However, risk factors associated with readmis…
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Risk Factors Associated With Perioperative Myocardial Infarction in Major Ope…
Among patients undergoing non-cardiac surgery, major vascular surgery is associated with a high risk of perioperative myocardial infarction (MI). Currently there are no perioperative MI risk calculators accounting for intraoperative and postoperative risk factors in vascular surgery patients. We aimed to investigate specific risk factors for perioperative MI after major open vascular surgery to…
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Vascular Surgery in Japan: 2011 Annual Report by the Japanese Society for Vas…
This is an annual report indicating the number and early clinical results of annual vascular treatments performed by vascular surgeons in Japan during 2011, as analyzed by database management committee (DBC) members of the Japanese Society for Vascular Surgery (JSVS
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Process Pharmacology: A Pharmacological Data Science Approach to Drug Develop…
A novel functional-genomics based concept of pharmacology that uses artificial intelligence techniques for mining and knowledge discovery in ‘‘big data’’ providing comprehensive information about the drugs’ targets and their functional genomics is proposed. In ‘‘process pharmacology’’, drugs are associated with biological processes. This puts the disease, regarded as altera…
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The current status and trend of clinical pharmacology in developing countries
Several international forums for promoting clinical pharmacology in developing countries have been held since 1980, and several clinical pharmacology programmes targeting developing countries were instituted such that the status of clinical pharmacology in developing countries is not where it was 50 years ago. Therefore, a survey and an appraisal of the literature on the current status of clini…
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