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Pathophysiology of atopic dermatitis: Clinical implications
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic predisposition, epidermal barrier disruption, and dysregulation of the immune system are some of the critical components of AD. An impaired skin barrier may be the initial step in the development of the atopic march as well as AD, which leads to further skin inflammation and allergic sensitization. Type 2 cytok…
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KDOQI CLINICAL PRACTICE GUIDELINE FOR NUTRITION IN CKD: 2020 UPDATE
The National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative (KDOQI) has provided evidence-based guidelines for nutrition in kidney diseases since 1999.Since the publication of the first KDOQI nutrition guideline, there has been a great accumulation of newevidence regarding the management of nutritional aspects of kidney disease and sophistication in the guidelines process. The…
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Salt and cardiovascular disease: insufficient evidence to recommend low sodiu…
Several blood pressure guidelines recommend low sodium intake (
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Orthopaedic traumatology: fundamental principles and current controversies fo…
Multiply injured patients with fractures are co-managed by acute care surgeons and orthopaedic surgeons. In most centers, orthopaedic surgeons definitively manage fractures, but preliminary management, including washouts, splinting, reductions, and external fixations, may be performed by selected acute care surgeons. The acute care surgeon should have a working knowledge of orthopaedic termino…
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The orthopaedic and traumatology scenario during Covid-19 outbreak in Italy: …
From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals’ organisation throughout Italy dramatically changed
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The role of virtual reality in improving motor performance as revealed by EEG…
Many studies have demonstrated the usefulness of repetitive task practice by using robotic-assisted gait training (RAGT) devices, including Lokomat, for the treatment of lower limb paresis. Virtual reality (VR) has proved to be a valuable tool to improve neurorehabilitation training. The aim of our pilot randomized clinical trial was to understand the neurophysiological basis of motor function …
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Desensitization Therapy for Allergic Reactions to Antituberculous Drugs
We retrospectively evaluated the clinical usefulness of desensitization therapy for many patients showing allergic reactions to anti-mycobacterial drugs (INH and RFP) according to the proposition reported by the Japanese Society for Tuberculosis (JST).
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Efficacy and patient-reported outcomes from a phase 2b, randomized clinical t…
Tapinarof is a topical therapeutic aryl hydrocarbon receptor modulating agent under investigation for atopic dermatitis (AD) and psoriasis treatment
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Dupilumab prevents flares in adults with moderate to severe atopic dermatitis…
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by flares, defined as worsening of the disease requiring escalation/intensification of AD treatment
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Nebulised N-Acetylcysteine for Unresponsive Bronchial Obstruction in Allergic…
Many chronic lung diseases are characterized by the hypersecretion of mucus. In these conditions, the administration of mucoactive agents is often indicated as adjuvant therapy. N-acetylcysteine (NAC) is a typical example of amucolytic agent. A retrospective review of patients with pulmonary aspergillosis treated at the National Aspergillosis Centre in Manchester,United Kingdom,with NAC between…
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