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Spironolactone vs placebo, Bisoprolol, and Doxazin to Determine the Optimal T…
Optimal drug treatment for patients with resistant hypertension is undefi ned. We aimed to test the hypotheses that resistant hypertension is most often caused by excessive sodium retention, and that spironolactone would therefore be superior to non-diuretic add-on drugs at lowering blood pressure.
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International Consensus on Risk Management of Diabetic Ketoacidosis in Patien…
Sodium glucose cotransporter (SGLT) inhibitors are new oral antidiabetic medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure and bodyrnweight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes
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Ambroxol Effects in Glucocerebrosidase and a-Synuclein Transgenic Mice
Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule c…
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Systematic Review of Group A Streptococcal emm Types Associated with Acute Po…
Acute post-streptococcal glomerulonephritis (APSGN) is a postinfectious immune-mediated kidney disease associated with group A Streptococcus (GAS). The prevalence of APSGN varies within and between countries and is influencedby socioeconomic, host, and bacterial factors. Thedisease ismoreprevalent in developing countries and resource-poor settings ofdeveloped countries, such as the Indigenou…
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Post-streptococcal acute glomerulonephritis complicated by gouty arthritis: a…
Gouty arthritis is uncommon in childhood and adolescence. On the other hand, there has been no report of cases with development of gouty arthritis with post-streptococcal acute glomerulonephritis (PSAGN) in pediatric patients. Here we report the case of a mildly obese 12-year-old boy with PSAGN complicated by gouty arthritis of the left first metatarsophalangeal joint. On follow-up, it was conf…
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Post-streptococcal glomerulonephritis leading to posterior reversible encepha…
Posterior reversible encephalopathy syndrome is a clinical radiographic syndrome of heterogeneous etiologies. Developing hypertensive encephalopathy following post-streptococcal glomerulonephritis is a known but uncommon manifestation and developing posterior reversible encephalopathy syndrome in such a situation is very rare. We report a case with contrast-enhanced computed tomography and m…
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Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Dono…
Post-streptococcal glomerulonephritis (PSGN) is a well-known cause of renal injury. This disease is caused by a prior infection with specific nephritogenic strains of group A beta-hemolytic streptococcus resulting in formation of immune complexes in the glomeruli. Clinical presentation can range from asymptomatic, microscopic hematuria to the nephritic syndrome which is defined by red to brown …
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Current Concepts of Premature Ventricular Contractions
Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle. PVCs are common with an estimated prevalence of 40% to 75% in the general population on 24- to 48-hour Holter monitoring. Traditionally, they have been thought to be relatively benign in the absence of structural heart disease but they represent increased risk of sudden death i…
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Premature Ventricular Contraction Coupling Interval Variability Destabilizes …
Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system (ICNS), a neural network on the heart, remai…
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Bridging the Great Divide: What Can Neurology Learn from Psychiatry?
Neurology and psychiatry share common historical origins and rely on similar tools to study brain disorders. Yet, the practical integration of medical and scientific approaches across these clinical neurosciences has remained elusive. While much has been written about the need to incorporate emerging systems-level, cellular-molecular and genetic-epigenetic advances into a science of mind for ps…
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