Channa striatus capsules induces cytokine conversion in pulmonary tuberculosi…

The rate of positive sputum smear decline was more pronounced in the Channa striatus group but did not reach statistically different value between groups. The levels of TNF-α, IFN-γ, and IL-10 were not significantly different in Channa striatus group compared to placebo group at baseline (week 0). But at week 12, the supplementation of Channa striatus capsule significantly decreased TNF-α, I…

Advances in rectal drug delivery systems

Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery of antipyretics. However, the recent trend is showing an increase in the development of novel rectal deliver…

Ketorolac, diclofenac and ketoprofen are equally safe for pain relief after m…

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Ketoprofen Pharmacokinetics, Efficacy, and Tolerability in Pediatric Patients

The NSAID ketoprofen is used widely in the management of inflammatory and musculoskeletal conditions, pain, and fever in children and adults. Pharmacokinetic studies show that drug exposure after a single intravenous dose is similar in children and adults (after dose normalization), and thus similar mg /kg bodyweight dosing may be used in children and adults. Ketoprofen crosses the blood-bra…

Analgesic Efficacy and Pharmacokinetics of Ketoprofen Administered into a Sur…

A series of three clini cal tri als in the oral sur gery model evalu -ated the anal gesic effi cacy and phar macokinetics of keto pro - fen admin is tered locally as a strat egy for decreas ing sys temic exposure to non ster oi dal anti- inflammatory drugs (NSAIDs). A gel for mu la tion was admin istered directly into extrac tion sites 1 hour fol lowing oral sur gery, and pain inten sity wa…

Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation C…

In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacologica…

The safety of ketoprofen in different ages

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID), which acts by blocking cyclooxygenase (COX 1 and 2), an enzyme involved in the production of prostaglandins, messengers in the development of inflammation. All NSAIDs reduce signs of inflammation by blocking this enzyme and therefore prostaglandin production. In Calabria, 3.69% of adverse drug reactions (ADRs) reported in the Nationa…

Comparison of the Efficacy and Safety of Ketoprofen Plaster and Diclofenac Pl…

To compare the efficacy and safety of ketoprofen plasters and diclofenac plasters after 3 weeks of administration in patients with osteoarthritis- related knee pain

Global strategy for asthma management and prevention update 2017

The reader acknowledges that this report is intended as an evidence-based asthma management strategy, for health professionals and policy makers. It is based, to the best if our knowledge, on current best evidence and medical knowledge and practice at the date of publication

Gabapentin misuse, abuse and diversion: a systematic review

Since its market release, gabapentin has been presumed to have no abuse potential and subsequently has been prescribed widely off-label, despite increasing reports of gabapentin misuse. This review estimates and describes the prevalence and effects of, motivations behind and risk factors for gabapentin misuse, abuse and diversion.