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Deep vein thrombosis: pathogenesis, diagnosis, and medical management
Deep vein thrombosis (DVT) is a major preventable cause of morbidity and mortality worldwide. Venous thromboembolism (VTE), which includes DVT and pulmonary embolism (PE), affects an estimated 1 per 1,000 people and contributes to 60,000–100,000 deaths annually. Normal blood physiology hinges on a delicate balance between pro- and anti-coagulant factors. Virchow’s Triad distills the multi…
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Deep venous thrombosis: a literature review
Abstract: Deep vein thrombosis (DVT) refers to the formation of thrombosis within the deep veins, dominantly occurring in the pelvis or lower limbs. This clinical syndrome has gained attention as one complication of DVT, pulmonary embolization, can be fatal. Therefore, early detection and systematic management of DVT and related complica tions are essential in clinical practice. As the clinica…
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Diversity and Distribution of Heavy Metal-Resistant Bacteria in Polluted Sed…
Heavy metals influence the population size, diversity, and metabolic activity of bacteria. In turn, bacteria can develop heavy metal resistance mechanisms, and this can be used in bioremediation of contaminated areas. The purpose of the present study was to understand how heavy metals concentration influence on diversity and distribution of heavy metal-resistant bacteria in Araça Bay, São Se…
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Prevalence of Childhood Eye Disease
Population or hospital-based studies of the epidemiology of childhood eye diseases in Turkey are limited. Therefore, we aimed to establish the eye disease and treatment frequencies in a cohort of children presenting to a single pediatric ophthalmology clinic in Istanbul. Material and Methods: This was a retrospective review of the hospital files of 500 children admitted to the pediatric ophthal…
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Immune Checkpoint Inhibitors in Hepatocellular Cancer: Current Understanding…
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide and a leading cause of death worldwide. Its incidence continues to increase in the US due to hepatitis C infection and nonalcoholic steatohepatitis. Liver transplantation and resection remain the best therapeutic options for cure, but these are limited by the shortage of available organs for transplantation,…
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Early events in the molecular pathogenesis of lung cancer
The majority of cancer-related deaths in the United States and worldwide are attributed to lung cancer. There are more than 90 million smokers in the United States who represent a signif- icant population at elevated risk for lung malignancy. In other epithelial tumors, it has been shown that if neoplastic lesions can be detected and treated at their intraepithelial stage, patient prognos…
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The Molecular Biology of Lung Cancer Pathogenesis
Lung cancers exhibit multiple genetic lesions including mutations activating the dominant cellular proto-oncogenes as well as those inactivating the recessive or "tumor suppressor" genes. Candidate tumor suppressor genes include those on chromosomes 1p, 1q, 3p14, 3p21.3, 3p25 (VHL gene), 5q21 (APC/MCC gene cluster), 9p21-22 (interferon gene cluster), 11p, 13q (rb gene), 16p24, and 17p (p53 gene…
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Social epidemiology and health economics: the need to find common grounds
There is an ever increasing number of studies focusing on health inequalities, expanding also into areas such as life course analyses and regional inequalities. By describing these inequalities in much detail, they continuously add to our understanding of the underlying causes, such as exposures during childhood and obesogenic envir- onment.
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Impact of Chronic Pain on Patients’ Quality of Life: A Comparative Mixed-…
Seventy-nine patients participated in the quantitative phase. The mean (standard deviation) age was 46.5 (14.5). Lower back (54; 68.3%) followed by lower limb were the most common pain sites. Compared with the general population and patients with long-term conditions, chronic pain patients had significantly lower mean QoL scores across all domains of SF-36 (All P < .05). Six themes emerged from…
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Role of fever and ambient temperature in COVID-19
The role of fever in COVID-19 has not been studied in large studies. In our review of the literature, only two studies have related the ambient temperature or fever to the outcomes of the COVID-19 patients. In a non-peer-reviewed observational study, the high ambient temperature was correlated with decreased mortality in COVID-19 patients in Wuhan and Hubei provinces; however, no data on …
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