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Sepsis and septic shock
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive,rnlong-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arisingrnfrom research in the past 10 years have increased understanding of this problem among clinicians and lay people, andrnhave led to improved outcomes. The World Hea…
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Competing risks model in screening for preeclampsia by maternal characteristi…
To develop a model for preeclampsia (PE) based on maternal demographic characteristics and medical history
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Genetic and non-genetic risk factors for pre-eclampsia: umbrella review of sy…
To summarize evidence from the literature on genetic and non-genetic risk factors associated with pre-eclampsia (PE), assess the presence of statistical bias in the studies and identify risk factors for which there is robust evidence supporting their association with PE.
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TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis
Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is known to stimulate neutrophil production and is widely used as a treatment of chemotherapy-induced neutropenia. A small-molecule G-CSF secretagogue wi…
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Granulocyte Colony Stimulating Factor Receptor (G-CSFR) signaling in severe c…
Granulocyte colony stimulating factor (G-CSF) is a hematopoietic cytokine that stimulates neutrophil production and hematopoietic stem cell mobilization by initiating the dimerization of homodimeric granulocyte colony stimulating factor receptor (G-CSFR). Different mutations of CSF3R have been linked to a unique spectrum of myeloid disorders and related malignancies. Myeloid disorders caused by…
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Occupational and Environmental Lung Disease
The association of occupational lung disease (OLD) with mining has been recognized since the 1500s when silica exposure and tuberculosis were described by Agricola.1 Occupational and environmental lung diseases still remain major causes of pulmonary impairment worldwide. Globally, Driscoll and colleagues2 report an estimated 386,000 respiratory deaths and almost 6.6 million disability adjusted…
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SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardio…
Chronic kidney disease (CKD) in patients with diabetes mellitus (DM) is a major problem of public health. currently, many of these patients experience progression of cardiovascular and renal disease, even when receiving optimal treatment. In previous years, several new drug classes for the treatment of type 2 DM have emerged, including inhibitors of renal sodium–glucose cotransporter-2 (SGLT…
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Pregnancy in women with systemic lupus erythematosus (SLE)
Formany years pregnancy has been contraindicated in patients with SLE, particularlywhen kidney involvement was present. Today, pregnancy is no longer considered impossible in women with lupus. Yet, lupus pregnancies are still considered high-risk. The prognosis has considerably improved for pregnant women but the fetal risk, although progressively reduced, is still higher in pregnancies of pati…
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Diagnosis of Hepatic Nodules in Patients at Risk for Q1 Hepatocellular Carcin…
Unequivocal diagnosis with avoidance of falsepositive results is very relevant in patients with liver disease in whom an imaging technique detects a nodule that raises the potential emergence of hepatocellular carcinoma (HCC). Although biopsy confirmation is standard in most cancers, several studies have shown that reliable HCC diagnosis may be established by imaging techniques in patients wit…
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Pola Penggunaan Antibiotik Profilaksis pada Pasien Bedah Caesar (Sectio Caesa…
Telah dilakukan penelitian pola penggunaan antibiotik profilaksis pada pasien bedah caesar (Seksio Sesare) di Rumah Sakit Pekanbaru Medical Center (PMC) tahun 2014. Tujuan penelitian ini untuk mengetahui pola penggunaan antibiotik profilaksis bedah sesar. Jenis penelitian yang dilakukan adalah penelitian observasional yang dirancang dengan studi deskriptif dengan cara melakukan kajian terhadap …
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