Development of pediatric neurosurgical service at Dr. Soetomo Hospital, Surab…

This review traces the history of pediatric neurosurgery at Dr. Soetomo General Hospital (DSGH) and its role in advancing the field of pediatric neurosurgery

Dual roles of yes-associated protein (YAP) in colorectal cancer

Yes-associated protein (YAP) is a downstream effector molecule of a newly emerging tumour suppressor pathway called the Hippo pathway. YAP is a transcriptional co-activator and mis-expressed in various cancers, including colorectal cancer (CRC). Accumulating studies show that the high expression of nuclear YAP is linked with tumour progression and decreased survival. Nuclear YAP can interact w…

Life threatening thyrotoxicosis: thyroid storm

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Substantial variation exists in spirometry interpretation practices for airfl…

Spirometry forms the foundation investigation for the diagnosis and monitoring of common pulmonary conditions. However, potential variation in spirometry interpretation for airflow obstruction may impact subsequent clinical management

Osteoporosis

Fractures resulting from osteoporosis become increasingly common in women after age 55 years and men after age 65 years, resulting in substantial bone-associated morbidities, and increased mortality and health-care costs. Research advances have led to a more accurate assessment of fracture risk and have increased the range of therapeutic options available to prevent fractures. Fracture risk …

Advances in radionuclide imaging of cardiac sarcoidosis

Radionuclide imaging for the diagnosis and monitoring of cardiac involvement in sarcoidosis has advanced significantly in recent years.

Management of chronic subdural haematoma: haematoma: burr holerndrainage, rep…

Although the treatment of chronic subdural haematoma by burr hole drainage has been performed inrnthe past with or without using a closed drainage system, the problem of intracranial air entrapment stillrnpersists and can cause a deterioration in the level of consciousness or seizures in the postoperative period.rnCerebral infarction may also develop a few days after surgery because of the intr…

CONTEMPORARY INITIAL ANTIBIOTIC THERAPY OF PRIMARY PLEURAL EMPYEMA

Approximately 15% of all of parapneumonic effusions progress into pleural empyema(PE). PE treatment includes evacuation of pus, re-expansion of lung along with use of antibiotics. Initial antibiotics treatment is often started with antibiotics that are resistant to causes found in microbiological isolates. Objective: definition of contemporary initial antibiotic therapy of PE which can be used …

Empyema management: A cohort study Q5 evaluating antimicrobial therapy

Empyemas require aggressive antimicrobial and surgical management. However, the specifics of antimicrobial therapy have not been studied in clinical trials. The present study examines management and outcomes among a cohort of patients with empyema cared for in a tertiary-care referral hospital over a decade

Defining of initial antibiotic treatment of pleural empyema

Parapneumonic effusions are often complications of bacterial pneumonia, occurring in 5-50% patients and in 15% cases it can progress into pleural empyema. Pleural empyema treatment includes drainage of pus, re-expansion of lung by using appropriate antibiotics. Initial antibiotics treatment of pleural empyema is usually started with antibiotics that are resistant to causes found in isolates.