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Kejadian Acute Kidney Injury dengan Kriteria pRIFLE pada Unit Perawatan Inten…
Dari 411 pasien yang dirawat di Unit Perawatan Intensif Anak, 149 (36,25%) dilakukan pemeriksaan blood urea nitrogen (BUN) dan serum kreatinin (SC). Terdapat 25 kasus (6,1%) merupakan kasus AKI. Sebagian besar subyek berusia di bawah 1 tahun (10/25) dan berjenis kelamin laki-laki 15/25. Berdasarkan kriteria pRIFLE, 3 termasuk dalam kriteria risk (R), 12 injury (I), dan 10 dimasukkan failure (F)…
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Acute Kidney Injury in Pediatric Severe Sepsis, An Independent Risk Factor fo…
The prevalence of septic acute kidney injury (AKI) and impact on functional status of pediatric intensive care unit (PICU) survivors are unknown. We utilized data from an international prospective severe sepsis study to elucidate functional outcomes of children suffering septic AKI.
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The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond
Osteoarthritis (OA) is a prevalent and debilitating joint disease for which ageing, obesity and chronic inflammation are known risk factors. The central, peripheral and autonomic nervous systems are essential in all metabolic systems, and emerging evidence suggests a role for these systems in OA
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Changes in the osteochondral unit during osteoarthritis: structure, function …
In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and trabecular bone form a biocomposite referred to as the osteochondral unit that is uniquely adapted to the transfer of load. During the evolution of the osteoarthritic process the compositions, functional properties, and structures of these tissues undergo marked alterations. Although pathologica…
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The changing role of TGFβ in healthy, ageing and osteoarthritic joints
Transforming growth factor‑β (TGFβ) is a pleiotropic cytokine that is important in the regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has an important function in maintaining the differentiated phenotype of articular chondrocytes
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The role of metabolism in the pathogenesis of osteoarthritis
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative prote…
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Osteoarthritis
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent. The concept of the pathophysiology is still evolving, from being viewed as cartilage-limited to a m…
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Treatment of severe autoimmune hemolytic anemia in B-cell chronic lymphocytic…
We read with interest the article by Karlsson et al.1 in Leukemia (2007), which reports five patients treated successfully with alemtuzumab (anti-CD52) for refractory autoimmune hemolytic anemia (AIHA) complicating B-cell chronic lymphocytic leukemia (B-CLL).
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Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria d…
Alemtuzumab, approved for multiple sclerosis (MS), can cause secondary autoimmune adverse events including thyroid disorders, immune thrombocytopenia (ITP), and glomerular nephropathies. Non-ITP autoimmune cytopenias are rarely reported.
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Life-threatening autoimmune warm hemolytic anemia following treatment for mul…
Alemtuzumab is a humanized monoclonal antibody directed at CD52 approved as a disease- modifying therapy for relapsing forms of multiple sclerosis (MS).
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